97-99-4, (Tetrahydrofuran-2-yl)methanol is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
97-99-4, Example 22CN-[(2Z)-5-tert-butyl-3-[2R)-tetrahydrofuran-2-ylmethyl]-1,3-thiazol-2(3H)-ylidene]-2-[(2R)-tetrahydrofuran-2-ylmethoxy]-5-(trifluoromethyl)benzamideIn a 50 mL round-bottomed flask, (R)-(tetrahydrofuran-2-yl)methanol (176 mg, 1.74 mmol) was dissolved in tetrahydrofuran (8 ml). Sodium t-butoxide (176 mg, 1.83 mmol) was added and stirred at room temperature for 20 min before Example 22B (375 mg, 0.87 mmol) in tetrahydrofuran (5 mL) was added and stirred for 2 hours. The reaction was quenched with saturated ammonium chloride solution and extracted with ethyl acetate (3¡Á20 ml). The organics were combined, washed with brine, dried with sodium sulfate, filtered, and concentrated in vacuo. The residue was purified by Analogix Intelliflash280 (SiO2, 0-30% hexanes in ethyl acetate) to afford the title compound (210 mg, 47% yield). 1H NMR (300 MHz, DMSO-d6) delta ppm 1.32 (s, 9H) 1.59-1.68 (m, 1H) 1.75-2.00 (m, 7H) 3.60-3.69 (m, 2H) 3.70-3.82 (m, 2H) 4.04-4.10 (m, 2H) 4.11-4.24 (m, 3H) 4.25-4.32 (m, 1H) 7.25 (s, 1H) 7.28 (d, J=8.82 Hz, 1H) 7.73 (dd, J=8.65, 1.87 Hz, 1H) 7.94 (d, J=2.37 Hz, 1H); MS (DCI/NH3) m/z 513 (M+H)+. Anal. calcd C25H31F3N2O4S: C, 58.58; H, 6.1; N, 5.47. Found: C, 58.34; H, 6.22; N, 5.28.
97-99-4 (Tetrahydrofuran-2-yl)methanol 7360, aTetrahydrofurans compound, is more and more widely used in various fields.
Reference£º
Patent; ABBOTT LABORATORIES; US2010/63022; (2010); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem