With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5061-21-2,2-Bromo-4-butanolide,as a common compound, the synthetic route is as follows.
5061-21-2, To a solution of 4-bromophenol (13.9 g, 0.078 mol) in 75 mL of DMF was added cesium carbonate(38 g, 1.5 eq.). It was then cooled to 0 C and ct-Bromo-y-butyrolactone (18 g, 1.4 eq.) was added.After the addition was completed, the mixture was stirred at RT overnight. It was quenched withwater and extracted with EtOAc (3x). The combined organic layer was washed with water (2x),brine and dried (Na2504). The residue after concentration was purified on a Biotage column using 5-50% EtOAc in hexane to give 3-(4-bromophenoxy)dihydrofuran-2(3H)-one (17 g, 85%).
The synthetic route of 5061-21-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; THE BRIGHAM AND WOMEN’S HOSPITAL, INC.; THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES; LEE, Arthur; MCKEW, John, C.; PATEL, Paresma, R.; YU, Paul, B.; MOHEDAS, Agustin, H.; SANDERSON, Philip, E.; ZHENG, Wei; HUANG, Xiuli; UNIVERSITY OF HOUSTON SYSTEM; CUNY, Gregory, D.; (304 pag.)WO2016/11019; (2016); A1;,
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