Chemical combination effects predict connectivity in biological systems was written by Lehar, Joseph;Zimmermann, Grant R.;Krueger, Andrew S.;Molnar, Raymond A.;Ledell, Jebediah T.;Hellbut, Adrian M.;Short, Glenn F. III;Giusti, Leanne C.;Nolan, Garry P.;Magid, Omar A.;Lee, Margaret S.;Borisy, Alexis A.;Stockwell, Brent R.;Keith, Curtis T.. And the article was included in Molecular Systems Biology in 2007.Formula: C11H13IN4O4 The following contents are mentioned in the article:
Efforts to construct therapeutically useful models of biol. systems require large and diverse sets of data on functional connections between their components. Here the authors show that cellular responses to combinations of chems. reveal how their biol. targets are connected. Simulations of pathways with pairs of inhibitors at varying doses predict distinct response surface shapes that are reproduced in a yeast experiment, with further support from a larger screen using human tumor cells. The response morphol. yields detailed connectivity constraints between nearby targets, and synergy profiles across many combinations show relatedness between targets in the whole network. Constraints from chem. combinations complement genetic studies, because they probe different cellular components and can be applied to disease models that are not amenable to mutagenesis. Chem. probes also offer increased flexibility, as they can be continuously dosed, temporally controlled, and readily combined. After extending this initial study to cover a wider range of combination effects and pathway topologies, chem. combinations may be used to refine network models or to identify novel targets. This response surface methodol. may even apply to non-biol. systems where responses to targeted perturbations can be measured. This study involved multiple reactions and reactants, such as (2R,3R,4S,5R)-2-(4-Amino-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol (cas: 24386-93-4Formula: C11H13IN4O4).
(2R,3R,4S,5R)-2-(4-Amino-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol (cas: 24386-93-4) belongs to tetrahydrofuran derivatives. Tetrahydrofuran (THF), or oxolane, is mainly used as a precursor to polymers. Being polar and having a wide liquid range, THF is a versatile solvent. THF can also be synthesized by catalytic hydrogenation of furan. This allows certain sugars to be converted to THF via acid-catalyzed digestion to furfural and decarbonylation to furan, although this method is not widely practiced. THF is thus derivable from renewable resources.Formula: C11H13IN4O4
Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem