Ramakrishna, Ubbani published the artcileDesign and synthesis of novel hydroxy-anthraquinone derivatives as anti-leishmanial agents, Recommanded Product: 3-Hydroxydihydrofuran-2(3H)-one, the publication is World Journal of Pharmaceutical Research (2017), 6(16), 759-764, database is CAplus.
A novel series of hydroxy-anthraquinone derivatives I [R = 1,2-di-OH, 2,3-di-OH, 1-Me-2,3-di-OH, etc.; R1 = 5-OH, 8-OH] was synthesized via Friedel-Crafts acylation reaction of phenols and hydroxyphthalic anhydride and identified as potential antileishmanial chemotype. Among the synthesized analogs I [R = 5-OH, R1 = 3,5-di-OH; R = 8-OH, R1 = 1,4-di-OH] exhibited better antileishmanial activity against intracellular amastigotes form of Leishmania donovani. The compounds I were also non-toxic toward Vero cells. Compounds I [R = 5-OH, 8-OH; R1 = 1,2-di-OH, 1,2,3-tri-OH] also showed significant in vitro activity against intracellular amastigotes form of Leishmania donovani.
World Journal of Pharmaceutical Research published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Recommanded Product: 3-Hydroxydihydrofuran-2(3H)-one.
Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem