With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.42417-39-0,3-Aminodihydrofuran-2(3H)-one hydrochloride,as a common compound, the synthetic route is as follows.,42417-39-0
Dissolving 3-chloro-4-(5-(4-isopropoxy-3-cyanophenyl)-1,2,4-oxadiazol-3-yl)benzaldehyde (200 mg, 0.54 mmol) In 35 ml of dichloromethane,Add to it in orderDL-homoserine lactone hydrochloride(112mg, 0.82mmol), glacial acetic acid (0.12ml, 2.18mmol), N,N-diisopropylethylamine (0.13ml, 0.82mmol), 5ml of methanol, reacted at room temperature for 3h, then added sodium cyanoborohydride (34mg , 0.47 mmol), reacted under argon for 5 h. A saturated sodium hydrogencarbonate solution was added, and the mixture was extracted with dichloromethane (3¡Á30 mL). Concentrated and separated by column chromatography. The eluent was dichloromethane: methanol = 20:1.A white solid 154 mg was obtained in a yield of 62.5%.
The synthetic route of 42417-39-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Chinese Academy Of Medical Sciences Pharmaceutical Institute; Wang Xiaojian; Liu Tianqi; Jin Jing; Hu Jinping; Chen Xiaoguang; Yin Dali; (70 pag.)CN109956912; (2019); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem