With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.88675-24-5,Tetrahydrofuran-3-amine,as a common compound, the synthetic route is as follows.
Example 4: 8-Chloro-7-methoxy-W-(tetrahydrofuran-3-yl)quinazolin-4-amine: To a solution of 4,8-dichloro-7-methoxyquinazoline (650 mg, 2.84 mmol) in dimethylformamide (20 mL) was added tetrahydrofuran-3-amine (297 mg, 3.41 mmol) and diisopropylethylannine (0.99 mL, 5.7 mmol). Through the mixture was bubbled N2 for 5 minutes. The reaction was then heated at 100¡ãC for 3 hrs under an atmosphere of N2. The crude mixture was concentrated and the residue was purified by flash chromatography on silica gel using a gradient of ethyl acetate and petroleum ether to give 8-chloro-7-methoxy-/V-(tetrahydrofuran-3-yl)quinazolin-4-amine 650 mg (82percent)., 88675-24-5
Big data shows that 88675-24-5 is playing an increasingly important role.
Reference£º
Patent; H. LUNDBECK A/S; KEHLER, Jan; RASMUSSEN, Lars Kyhn; LANGGARD, Morten; WO2015/150254; (2015); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem