111769-27-8, (R)-Tetrahydrofuran-3-amine 4-methylbenzenesulfonate is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A mixture of l-methyl-5-(2-phenyl-[l,2,4]triazolo[l,5-a]pyridin-7-ylcarbamoyl)-lH-pyrazole-4- carboxylic acid (100 mg, 276 muiotaetaomicron), (R)-tetrahydrofuran-3-ylamine 4-methylbenzenesulfonate (143 mg, 552 muiotaetaomicron), diisopropylethylamine (193 mu, 1.1 mmol) and propylphosphonic anhydride (50% in ethyl acetate, 407 mu, 690 muiotaetaomicron) in tetrahydrofurane (7 ml) is refluxed for 18 hours. The solvent is evaporated and to the residue is added sat. aqueous sodium hydrogencarbonate solution. The mixture is stirred for 20 minutes while a white solid precipitates. The solid is collected by filtration, washed with diethylether and dried affording (R)-l-methyl-N5-(2-phenyl- [l,2,4]triazolo[l,5-a]pyridin-7-yl)-N4-(tetrahydrofuran-3-yl)-lH-pyrazole-4,5-dicarboxamide (114 mg, 95.7%) as a white solid, mp.: > 250C. MS: m/z= 432.3 (M+H+).
111769-27-8, The synthetic route of 111769-27-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; FLOHR, Alexander; GOBBI, Luca; GROEBKE ZBINDEN, Katrin; KOERNER, Matthias; PETERS, Jens-Uwe; WO2012/76430; (2012); A1;,
Tetrahydrofuran – Wikipedia
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