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A little inspiration: The systematic preparation of sixteen natural product-inspired polyhydroylated pyrrolidine-based isomeric scaffolds is described. Each scaffold possesses four stereogenic centers and one exo-aminomethyl moiety, which allows for rapid substituent diversity. To exemplify biological applications, these new privileged scaffolds were used to discover new human Golgi alpha-mannosidase II inhibitors. The most potent inhibitor shows competitive behavior with a Ki value of 24 nM. Copyright
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Synthetic Route of 89364-31-8. In my other articles, you can also check out more blogs about 89364-31-8
Reference：
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem