With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.17347-61-4,2,2-Dimethylsuccinicanhydride,as a common compound, the synthetic route is as follows.
A stirring solution of compound 24-1 (55 mg, 0.10 mmol), DMAP (14.8 mg, 0.12 mmol) and 2,2-dimethylsuccinic anhydride (38.7 mg, 0.30 mmol) in dry pyridine (1.0 mL) is heated at 1200C for 4 hours. Another 0.30 mmol of 2,2-dimethylsuccinic anhydride is added and heating at 12O0C is continued for 24 hours. The mixture is cooled down to room temperature and concentrated to dryness. The residue is diluted in ethyl acetate, washed twice with HCl 1 N, water and brine, dried over sodium sulfate and concentrated to dryness. The residue is purified by flash column chromatography on silica gel (methanol/ DCM 0percent to 10percent) to yield the title compound 19-2 as a white solid (48 mg, 71percent).
17347-61-4, As the paragraph descriping shows that 17347-61-4 is playing an increasingly important role.
Reference£º
Patent; VIROCHEM PHARMA INC.; WO2009/82819; (2009); A1;,
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