97-99-4, (Tetrahydrofuran-2-yl)methanol is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,97-99-4
Example 1 : Lambda/-((2S)-5-{[(2/?)-tetrahydro-2-furanylmethyl]oxy}-2,3-dihydro-1H-inden-2- yl)-2-propanesulfonamide; To a solution of Lambda/-[(2S)-5-hydroxy-2,3-dihydro-1 H-inden-2-yl]-2-propanesulfonamide (300 mg, 1.175 mmol, Description 3) and (2R)-tetrahydro-2-furanylmethanol (0.125 ml, 1.292 mmol) in dichloromethane (6 ml) was added DIAD (0.228 ml, 1.175 mmol) followed by triphenylphosphine (308 mg, 1.175 mmol). The reaction mixture was stirred at 25 0C overnight. 75 mul of (2/?)-tetrahydro-2-furanylmethanol, 0.115 ml of DIAD and 150 mg of triphenylphosphine were added to the reaction mixture which was stirred at room temperature overnight again.Solvent was removed and the residue was partitioned between water (10 ml) and EtOAc (30 ml). The aqueous phase was further extracted with EtOAc (30 ml). Organics were dried over MgSO4 and concentrated to give crude product which was purified by reverse phase chromatography using the MDAP. Relevant fractions were combined and concentrated to give the title compound as a white solid (170 mg).LC/MS (ES): Found 340 (ES+), retention time 0.97 mins (2 minute method). C17H25NO4S requires 339.1H NMR (400 MHz, MeOH-d4) delta 1.35 (d, J=6.8 Hz, 6 H), 1.69 – 1.85 (m, 1 H), 1.86 – 2.14(m, 3 H), 2.73 – 2.93 (m, 2 H), 3.10 – 3.28 (m, 3 H), 3.76 – 3.84 (m, 1 H), 3.85 – 3.97 (m, 3H), 4.16 (quintet, J=7.5 Hz, 1 H), 4.19 – 4.26 (m, 1 H), 6.73 (dd, J=8.0, 2.4 Hz, 1 H), 6.78(s, 1 H), 7.06 (d, J=8.3 Hz, 1 H).
The synthetic route of 97-99-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; GLAXO GROUP LIMITED; WARD, Simon, E; BERTHELEME, Nicolas; WO2010/37760; (2010); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem