Differential acidimetric determination of the components of nucleic acids, their derivatives, and mixtures in a methyl cellosolve medium was written by Veveris, A.;Spince, B.;Smolova, N. T.. And the article was included in Zhurnal Analiticheskoi Khimii in 1981.Safety of Sodium ((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate This article mentions the following:
The proton-acceptor properties of many purine and pyrimidine amino derivatives were examined in methyl cellosolve (MC). Dissociation constant values indicate that in spite of many H+-acceptor groups in these derivatives (NH2, heterocyclic N), these compounds are protonated in MC and H2O as monobasic compounds (except 6-histaminopurine). H+ may be attached to different groups depending on the structure of these derivatives In cytidine, the protonation is at the heterocyclic N at position 3, and adenosine and guanosine with different heterocycles are protonated at 1 (in pyrimidine) and 7 (in imidazole, resp.). The differences in the dissociation constants were large for cytosine and guanosine derivatives Procedures were developed for differential titrimetric procedures for these compounds in binary and ternary mixtures with HClO4 in MC. In the experiment, the researchers used many compounds, for example, Sodium ((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate (cas: 6757-06-8Safety of Sodium ((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate).
Sodium ((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate (cas: 6757-06-8) belongs to tetrahydrofuran derivatives. Tetrahydrofuran and dihydrofuran form the basic structural unit of many naturally occurring scaffolds like gambieric acid A and ciguatoxin, goniocin, and some biologically active molecules. Tetrahydrofuran reaction with hydrogen sulfide: In the presence of a solid acid catalyst, tetrahydrofuran reacts with hydrogen sulfide to give tetrahydrothiophene.Safety of Sodium ((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate
Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem