Sodium ((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate (cas: 6757-06-8) belongs to tetrahydrofuran derivatives. Tetrahydrofuran (THF), or oxolane, is mainly used as a precursor to polymers. Being polar and having a wide liquid range, THF is a versatile solvent. THF (Tetrahydrofuran) is also used as a starting material for the synthesis of poly(tetramethylene ether) glycol (PTMG), etc.COA of Formula: C9H12N3Na2O8P
Biochemical studies of taste sensation. IX. Enhancement of L-[3H]-glutamate binding to bovine taste papillae by 5′-ribonucleotides was written by Torii, Kunio;Cagan, Robert H.. And the article was included in Biochimica et Biophysica Acta, General Subjects in 1980.COA of Formula: C9H12N3Na2O8P This article mentions the following:
Binding of tritium-labeled L-glutamate [56-86-0] was measured to preparations of bovine circumvallate (taste) papillae (type I preparation) and to control tongue epithelial preparations (type II preparation) devoid of taste receptors. Substantially greater binding occurred to the type I preparation than to the type II preparation, and the binding to the type I preparation showed evidence of saturation The apparent Kd of L-glutamate was 20-30 mM. A several-fold enhancement of binding of L-glutamate-3H occurred in the presence of certain 5′-ribonucleotides. 5′-GMP di-Na salt [5550-12-9], 5′-IMP di-Na salt [4691-65-0], and 5′-UMP di-Na salt [3387-36-8] each increased the binding of L-glutamate-3H, whereas 5′-XMP di-Na salt [25899-70-1], 5′-AMP di-Na salt [4578-31-8], and 5′-CMP di-Na salt [6757-06-8] did not. None of these nucleotides affected the lower level of binding to the type II preparation Neither the free bases, adenine [73-24-5] and guanine [73-40-5], their nucleosides nor their di- or triphosphononucleotides were effective in increasing L-glutamate-3H binding to the type I preparation The nucleotide specificity of the glutamate binding enhancement therefore shows a marked similarity with the nucleotide specificity in evoking the synergistic taste effect in humans. Using 5′-GMP stimulation as a model, it appeared that the major effect was to increase the maximum binding of L-glutamate-3H, but no marked change in Kd was apparent. The 5′-ribonucleotide may act to increase the extent of L-glutamate binding by unmasking previously hidden or buried receptor sites for L-glutamate. In the experiment, the researchers used many compounds, for example, Sodium ((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate (cas: 6757-06-8COA of Formula: C9H12N3Na2O8P).
Sodium ((2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl phosphate (cas: 6757-06-8) belongs to tetrahydrofuran derivatives. Tetrahydrofuran (THF), or oxolane, is mainly used as a precursor to polymers. Being polar and having a wide liquid range, THF is a versatile solvent. THF (Tetrahydrofuran) is also used as a starting material for the synthesis of poly(tetramethylene ether) glycol (PTMG), etc.COA of Formula: C9H12N3Na2O8P
Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem