Bresnick, Edward et al. published their research in Cancer Research in 1962 | CAS: 10356-76-0

4-Amino-5-fluoro-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 10356-76-0) belongs to tetrahydrofuran derivatives. Solid acid catalysis, and the advantages often associated with their use, have been proved equally efficient for the synthesis of tetrahydrofurans or furans. It is more basic than diethyl ether and forms stronger complexes with Li+, Mg2+, and boranes. It is a popular solvent for hydroboration reactions and for organometallic compounds such as organolithium and Grignard reagents.SDS of cas: 10356-76-0

Feedback inhibition of asparate transcarbamylase in liver and in hepatoma was written by Bresnick, Edward. And the article was included in Cancer Research in 1962.SDS of cas: 10356-76-0 This article mentions the following:

Partially purified asparate transcarbamylase (I) from rat liver, Morris hepatoma 5123-A or D, Hepatoma 7800, and Novikoff hepatoma, was shown to be inhibited by pyrimidine deoxyribonucleosides and deoxyribonucleotides. The pyrimidine analogs, 5-bromo-2′-deoxyuridine, 5-bromouridine, 5-bromo-2′-deoxycytidine, 5-fluoro-2′-deoxyuridine, 5-fluorouridine, 5-fluoro-2′-deoxycytidine, 5-iodo-2-deoxyuridine, also inhibited enzymic activity. The most effective inhibitors were 2′-deoxyadenosine 5′-monophosphate (or 2′-deoxyguanosine 5′-monophosphate) and 2′-deoxyadenosine (II) or 2′-deoxyguanosine (III). I was identical in liver and in the hepatomas by pH optimum, Km values for carbamoyl phosphate and asparate, Vmaximum degree of inhibition by Cu++, by the pyrimidines, and by the inhibition constants Neg. feedback inhibition of pyrimidine biosynthesis occurs in hepatomas as well as in liver, and to the same extent. Furthermore, the control of I by II (or III) may play a significant role in vivo. In the experiment, the researchers used many compounds, for example, 4-Amino-5-fluoro-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 10356-76-0SDS of cas: 10356-76-0).

4-Amino-5-fluoro-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (cas: 10356-76-0) belongs to tetrahydrofuran derivatives. Solid acid catalysis, and the advantages often associated with their use, have been proved equally efficient for the synthesis of tetrahydrofurans or furans. It is more basic than diethyl ether and forms stronger complexes with Li+, Mg2+, and boranes. It is a popular solvent for hydroboration reactions and for organometallic compounds such as organolithium and Grignard reagents.SDS of cas: 10356-76-0

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem