Month: November 2022

Timoshchuk, Victor A. published the artcileImproved and Reliable Synthesis of 3′-Azido-2′,3′-dideoxyguanosine Derivatives, COA of Formula: C26H45N5O7Si2, the publication is Nucleosides, Nucleotides & Nucleic Acids (2004), 23(1 & 2), 171-181, database is CAplus and MEDLINE.

An improved synthesis of N²-protected-3′-azido-2′,3′-dideoxyguanosine is described. Deoxygenation of 2′-O-alkyl (and/or aryl) sulfonyl-5′-dimethoxytritylguanosine coupled with [1,2]-hydride shift rearrangement gave protected 9-(2-deoxythreo-pentofuranosyl)guanines. This rearrangement was accomplished in high yield with a high degree of stereoselectivity using lithium triisobutylborohydride (L-Selectride). The resulting 2-deoxythreo-pentofuranosyl derivatives were transformed into 3′-O-mesylates, which can be used for 3′-substitution. The 3′-azido nucleosides were obtained by treatment of the 3′-O-mesylates with lithium azide. This procedure is reproducible with a good overall yield.

Nucleosides, Nucleotides & Nucleic Acids published new progress about 87865-78-9. 87865-78-9 belongs to tetrahydrofurans, auxiliary class Nucleosides and Nucleotides,Nucleoside Analogues, name is N-(9-((6aR,8R,9R,9aS)-9-Hydroxy-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide, and the molecular formula is C17H18N2O6, COA of Formula: C26H45N5O7Si2.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Groenewold, Gary S. published the artcileSignatures of Biologically Driven Hemicellulose Modification Quantified by Analytical Pyrolysis Coupled with Multidimensional Gas Chromatography Mass Spectrometry, Safety of 3-Hydroxydihydrofuran-2(3H)-one, the publication is ACS Sustainable Chemistry & Engineering (2020), 8(4), 1989-1997, database is CAplus.

Biomass storage conditions are a major source of feedstock quality variability that impact downstream preprocessing, feeding, handling and conversion into biofuels, chems. and products. Microbial activity in the stored biomass can result in heating that can modify or degrade the cell walls of the biomass, changing its characteristics. Anal. pyrolysis has been used to characterize biomass, but at temperatures typically used (∼600°C), differentiation of samples having different storage histories is subtle or non-existent. In this study, lower-temperature (400°C) pyrolysis was used to show large differences in corn stover samples that had experienced different biol. heating histories, indicated by pyrolysis products that were identified, and in several cases quantified using two-dimensional gas chromatog. / mass spectrometry. Pyrolysis of the samples originating from biomass that had experienced biol. heating during storage generated small oxygenates such as furfural, 5-Me furfural and 2-(5H)-furanone with efficiencies that were as much as ten times greater than those measured for samples that were not significantly heated. Most of the pyrolysis products with enhanced efficiencies were C5 oxygenates, suggesting formation from hemicellulosic precursor polymers in the corn stover. The findings suggest that biol. heating is disrupting the cell wall structure, fragmenting the hemicellulose or cellulose chains, and generating more polymer termini that have higher efficiency for generating the oxygenates at lower temperatures Further, anal. pyrolysis conducted at lower temperatures may be a beneficial strategy for improved biomass cell wall characterization, and for providing insights to understand and manage the feedstock variability to inform harvest and storage best management practices.

ACS Sustainable Chemistry & Engineering published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Safety of 3-Hydroxydihydrofuran-2(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Lin, Yu-Len published the artcileCharacterization of bio-oils from fast pyrolysis of thorny bamboo (Bambusa stenostachya) and long-branch bamboo (B. dolichoclada), Category: tetrahydrofurans, the publication is Taiwan Linye Kexue (2013), 28(4), 203-216, database is CAplus.

In this study, thorny bamboo (Bambusa stenostachya) and long-branch (B. dolichoclada) bamboo were integrated as feedstock to produce pyrolysis liquid (bio-oil) using fast pyrolysis technol., and the basic properties of the bio-oils were analyzed. Results showed that the higher heating value (HHV) of both bio-oils were 13.92 MJ/kg for thorny bamboo and 14.87 MJ/kg for long-branch bamboo, and both HHVs were relatively low for use as bioenergy. The bio-oils need to be reprocessed using upgrading technologies to promote the efficiency of energy utilization. However, both bio-oils were analyzed by gas chromatog. mass spectrometry (GC-MS) and were shown to contain more than 80 different organic compounds with multifunctional groups. The major compounds in the bio-oil of long-branch bamboo were phenols with the largest proportion of >50%, and those of thorny bamboo included good distributions of phenols, carboxylic acids, and ketones. Both bio-oils are great potential resources beyond just a fossil fuel to provide various chem. compounds

Taiwan Linye Kexue published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Category: tetrahydrofurans.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Pearson, David published the artcileLC-MS based quantification of 2′-ribosylated nucleosides Ar(p) and Gr(p) in tRNA, HPLC of Formula: 87865-78-9, the publication is Chemical Communications (Cambridge, United Kingdom) (2011), 47(18), 5196-5198, database is CAplus and MEDLINE.

RNA nucleosides are often naturally modified into complex noncanonical structures with key biol. functions. Here the authors report LC-MS quantification of the Ar(p) and Gr(p) 2′-ribosylated nucleosides in tRNA using deuterium labeled standards, and the first detection of Gr(p) in complex fungi.

Chemical Communications (Cambridge, United Kingdom) published new progress about 87865-78-9. 87865-78-9 belongs to tetrahydrofurans, auxiliary class Nucleosides and Nucleotides,Nucleoside Analogues, name is N-(9-((6aR,8R,9R,9aS)-9-Hydroxy-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide, and the molecular formula is C26H45N5O7Si2, HPLC of Formula: 87865-78-9.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Alvarez, Alejandro published the artcileAroma compounds produced by liquid fermentation with Saccharomyces cerevisiae and Zygosaccharomyces rouxii from castor oil through cell permeabilization, Safety of 3-Hydroxydihydrofuran-2(3H)-one, the publication is Biocatalysis and Agricultural Biotechnology (2022), 102243, database is CAplus.

The use of microorganisms to produce aroma mols. is growing in the flavor and fragrance industries due to the increased market for natural products. In this study, the effect of the type of microorganism, and cellular permeabilization on the production of aroma mols. from castor oil by liquid fermentation with yeasts, was assessed for possible application in the production of natural flavors. Different treatments were assessed with a three-way factorial design (type of microorganism, cell permeabilization and amount of castor oil), the aroma profile was analyzed using gas chromatog. with mass spectrometry (GC-MS), and the treatments were classified by principal component anal. (PCA). The results showed a significant effect of the yeast S. cerevisiae and Z. rouxii, the permeabilization treatment, and the amount of castor oil in the production of aroma compounds (p < 0.05). The mols. 4-hydroxy-2-pentenoic acid γ-lactone, Me pyruvate, 2,3,4-trimethyl-3-pentanol, and δ-decalactone were affected by all the factors. The production of metabolites increased with the permeabilization treatments for certain mols. like ethanol and organic acids, whereas the generation of others decreased. The use of these microorganisms and cell permeabilization are promising approaches for producing mols. with applications in natural flavors.

Biocatalysis and Agricultural Biotechnology published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Safety of 3-Hydroxydihydrofuran-2(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Vats, Sharad published the artcileEvaluation of bioactive compounds and antioxidant potential of hydroethanolic extract of Moringa oleifera Lam. from Rajasthan, India, Application In Synthesis of 19444-84-9, the publication is Physiology and Molecular Biology of Plants (2017), 23(1), 239-248, database is CAplus and MEDLINE.

Moringa oleifera Lam., the miracle tree, is widely used as a traditional medicine. The analyses of phytochems. and antioxidant potential of hydroethanolic extract of various plant parts of M. oleifera revealed that leaves possessed the highest content of total phenolics (9.58 mg/g), β-carotene (14.10 mg/g) and lycopene (2.60 mg/g). Flowers and bark showed the highest content of total flavonoids (3.5 mg/g) and anthocyanin (52.80 mg/g), resp. Leaves also showed maximum antioxidant potential using nitric oxide scavenging assay (IC₅₀ – 120 μg/mL) and deoxyribose degradation assay (IC₅₀-178 μg/mL). Highest DPPH radical scavenging activity was observed in flowers (IC₅₀-405 μg/mL). The GC-MS study revealed the presence of 29, 36 and 24 compounds in bark, leaf and flower, resp. The major constituent identified were epiglobulol (41.68% in bark), phytol (23.54% in leaf) and β-sitosterol (15.35% in flower). The phytochems. identified possess several therapeutic activity, including antioxidant potential, which was confirmed through earlier reports. Moreover, the presence of 1,1,3-triethoxubutane in all the plant parts analyzed, projects it as an important source of waste water treatment as hydrophobic modifiers.

Physiology and Molecular Biology of Plants published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C6H11BF3KO, Application In Synthesis of 19444-84-9.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Lin, Shaoying published the artcileEfficient Production of Biomass-Derived C₄ Chiral Synthons in Aqueous Solution, Related Products of tetrahydrofurans, the publication is ChemCatChem (2017), 9(22), 4179-4184, database is CAplus.

Carbohydrates are expected to replace petroleum and to become the base of industrial chem. Chirality is one particular area in which carbohydrates have a special potential advantage over petroleum resources. Herein, we report a catalytic approach for the direct production of D-tetroses [i.e., D-(-)-erythrose and D-(+)-erythrulose] from D-hexoses through a fast retro-aldol process at 190° that achieves a yield of 46 % and completely retains the chiral centers in the final chiral synthon. The D-tetrose products were further converted into their derivatives, thereby accomplishing transfer of chirality from natural chiral hexoses to high-value-added chiral chems. Our results also suggest that the product distribution for the conversion of D-hexoses was determined by their isomerization and epimerization trends that competed with their corresponding retro-aldol condensation processes.

ChemCatChem published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Related Products of tetrahydrofurans.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Beijer, Barbro published the artcileSimplified and cost effective syntheses of fully protected phosphoramidite monomers suitable for the assembly of oligo(2′-O-allylribonucleotides), Category: tetrahydrofurans, the publication is Nucleosides & Nucleotides (1994), 13(9), 1905-27, database is CAplus.

Simplified, high yielding syntheses of suitably protected 2′-O-allylribonucleoside-3′-O-phosphoramidites starting from standard ribonucleosides have been elucidated. Specific 2′-O-allylation is readily achieved using amidine protection of the exocyclic amino groups of adenosine and cytidine and in the case of guanosine the allylation is carried out on an easily prepared intermediate bearing transient protection of the lactam function.

Nucleosides & Nucleotides published new progress about 87865-78-9. 87865-78-9 belongs to tetrahydrofurans, auxiliary class Nucleosides and Nucleotides,Nucleoside Analogues, name is N-(9-((6aR,8R,9R,9aS)-9-Hydroxy-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide, and the molecular formula is C26H45N5O7Si2, Category: tetrahydrofurans.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Karpeisky, Alexander published the artcile2′-O-Methylthiomethyl modifications in hammerhead ribozymes, Synthetic Route of 87865-78-9, the publication is Nucleosides & Nucleotides (1997), 16(7-9), 955-958, database is CAplus.

The synthesis of all four phosphoramidites of 2′-O-methylthiomethyl ribonucleosides and their incorporation into hammerhead ribozymes and influence on nuclease stability and catalytic activity is described.

Nucleosides & Nucleotides published new progress about 87865-78-9. 87865-78-9 belongs to tetrahydrofurans, auxiliary class Nucleosides and Nucleotides,Nucleoside Analogues, name is N-(9-((6aR,8R,9R,9aS)-9-Hydroxy-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide, and the molecular formula is C26H45N5O7Si2, Synthetic Route of 87865-78-9.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Liang, Jian-lan published the artcileChanges of aroma components in ‘Yanlong’ chestnut during storage, Category: tetrahydrofurans, the publication is Guoshu Xuebao (2014), 31(3), 410-414, database is CAplus.

This article was to study the changes of aroma components in ‘Yanlong’ chestnut during storage. The aroma components in chestnut stored 30 days, 90 days and 150 days, resp., were collected using solvent extraction, and analyzed by gas chromatograph-mass spectrophotometer (GC-MS). Totally 27 compounds were identified. Esters, ketones, aldehydes and alcs. were the major constituents. The aroma components accumulated differently during the storage. There were 17 components identified after storage for 30 days, 22 after 90 days and 22 after 150 days. During storage, the contents of esters and alkenes increased, and the contents of ketones and acids raised within 90 days and then kept stable, while the contents of alcs. showed highest after stored for 30 days and decreased until 90 days, then changed a little. Butyrolactone, 2-hydroxy-gamma-butyrolactone, 2,5-dimethyl-4-hy-droxy-3 (2H)-furanone, 4H-pyran-4-one, 2,3-dihydro-3,5-dihydroxy-6-methyl-, furfural and 5-(hydroxymethyl)-2-Furancarboxaldehyde might be the characteristic aroma constituents of ‘Yanlong’ chestnut. Under the certain storage condition, the best time for tasting chestnut food was within 90 days after storage.

Guoshu Xuebao published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Category: tetrahydrofurans.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem