The potential of intentional drug development was written by Rubin, Eric J.;Baden, Lindsey R.. And the article was included in New England Journal of Medicine in 2022.Safety of ((2R,3S,4R,5R)-3,4-Dihydroxy-5-((Z)-4-(hydroxyimino)-2-oxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl isobutyrate The following contents are mentioned in the article:
At the start of the Covid-19 pandemic more than 2 years ago, hopes were high for rapid interventions that could lessen the severity of disease and save lives. Several approved and investigational drugs had some in vitro activity against the causative virus, SARS-CoV-2. Two investigational agents, remdesivir and molnupiravir, eventually showed some clin. efficacy. But both have considerable drawbacks; remdesivir is available only as a parenteral formulation, and molnupiravir has only a modest effect. Studies of these drugs, along with monoclonal antibodies, did make one point clear: intervention with antiviral agents is possible, but only early in the course of disease. This study focus on effectiveness of the above mentioned drugs administered in patients during Covid-19 trial. This trial was performed between mid-July and early Dec. 2021, a period when the delta variant was most likely responsible for the majority of infections. Until authors have a better idea of the potential for emergence of resistance, they need to be good stewards of this medication. This study involved multiple reactions and reactants, such as ((2R,3S,4R,5R)-3,4-Dihydroxy-5-((Z)-4-(hydroxyimino)-2-oxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl isobutyrate (cas: 2492423-29-5Safety of ((2R,3S,4R,5R)-3,4-Dihydroxy-5-((Z)-4-(hydroxyimino)-2-oxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl isobutyrate).
((2R,3S,4R,5R)-3,4-Dihydroxy-5-((Z)-4-(hydroxyimino)-2-oxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl isobutyrate (cas: 2492423-29-5) belongs to tetrahydrofuran derivatives.Tetrahydrofuran has many industry uses as a solvent including in natural and synthetic resins, high polymers, fat oils, rubber, polymer. It is more basic than diethyl ether and forms stronger complexes with Li+, Mg2+, and boranes. It is a popular solvent for hydroboration reactions and for organometallic compounds such as organolithium and Grignard reagents.Safety of ((2R,3S,4R,5R)-3,4-Dihydroxy-5-((Z)-4-(hydroxyimino)-2-oxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl isobutyrate
Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem