Timoshchuk, Victor A.’s team published research in Nucleosides, Nucleotides & Nucleic Acids in 23 | CAS: 87865-78-9

Nucleosides, Nucleotides & Nucleic Acids published new progress about 87865-78-9. 87865-78-9 belongs to tetrahydrofurans, auxiliary class Nucleosides and Nucleotides,Nucleoside Analogues, name is N-(9-((6aR,8R,9R,9aS)-9-Hydroxy-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide, and the molecular formula is C17H18N2O6, COA of Formula: C26H45N5O7Si2.

Timoshchuk, Victor A. published the artcileImproved and Reliable Synthesis of 3′-Azido-2′,3′-dideoxyguanosine Derivatives, COA of Formula: C26H45N5O7Si2, the publication is Nucleosides, Nucleotides & Nucleic Acids (2004), 23(1 & 2), 171-181, database is CAplus and MEDLINE.

An improved synthesis of N2-protected-3′-azido-2′,3′-dideoxyguanosine is described. Deoxygenation of 2′-O-alkyl (and/or aryl) sulfonyl-5′-dimethoxytritylguanosine coupled with [1,2]-hydride shift rearrangement gave protected 9-(2-deoxythreo-pentofuranosyl)guanines. This rearrangement was accomplished in high yield with a high degree of stereoselectivity using lithium triisobutylborohydride (L-Selectride). The resulting 2-deoxythreo-pentofuranosyl derivatives were transformed into 3′-O-mesylates, which can be used for 3′-substitution. The 3′-azido nucleosides were obtained by treatment of the 3′-O-mesylates with lithium azide. This procedure is reproducible with a good overall yield.

Nucleosides, Nucleotides & Nucleic Acids published new progress about 87865-78-9. 87865-78-9 belongs to tetrahydrofurans, auxiliary class Nucleosides and Nucleotides,Nucleoside Analogues, name is N-(9-((6aR,8R,9R,9aS)-9-Hydroxy-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide, and the molecular formula is C17H18N2O6, COA of Formula: C26H45N5O7Si2.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem