Day: November 21, 2022

Bartoszewicz, Agnieszka published the artcileEnantioconvergent Alkylations of Amines by Alkyl Electrophiles: Copper-Catalyzed Nucleophilic Substitutions of Racemic α-Halolactams by Indoles, SDS of cas: 19444-84-9, the publication is Journal of the American Chemical Society (2019), 141(37), 14864-14869, database is CAplus and MEDLINE.

Transition-metal catalysis has the potential to address shortcomings in the classic S_N2 reaction of an amine with an alkyl electrophile, both with respect to reactivity and to enantioselectivity. The authors describe the development of a user-friendly method (reaction at room temperature, with com. available catalyst components) for the enantioconvergent nucleophilic substitution of racemic secondary alkyl halides (α-iodolactams) by indoles. Mechanistic studies are consistent with the formation of a copper(I)-indolyl complex that reacts at different rates with the two enantiomers of the electrophile, which interconvert under the reaction conditions (dynamic kinetic resolution). This study complements earlier work on photoinduced enantioconvergent N-alkylation, supporting the premise that this important challenge can be addressed by a range of strategies.

Journal of the American Chemical Society published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, SDS of cas: 19444-84-9.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Brzezinska, Jolanta published the artcileNon-nucleosidic analogues of polyaminonucleosides and their influence on thermodynamic properties of derived oligonucleotides, Quality Control of 19444-84-9, the publication is Molecules (2015), 20(7), 12652-12669, database is CAplus and MEDLINE.

The rationale for the synthesis of cationic modified nucleosides is higher expected nuclease resistance and potentially better cellular uptake due to an overall reduced neg. charge based on internal charge compensation. Due to the ideal distance between cationic groups, polyamines are perfect counterions for oligodeoxyribonucleotides. We have synthesized non-nucleosidic analogs built from units that carry different diol structures instead of sugar residues and functionalized with polyamines. The non-nucleosidic analogs were attached as internal or 5′-terminal modifications in oligodeoxyribonucleotide strands. The thermodn. studies of these polyaminooligonucleotide analogs revealed stabilizing or destabilizing effects that depend on the linker or polyamine used.

Molecules published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Quality Control of 19444-84-9.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Ye, Jiaxin published the artcileTranscriptome analysis identifies key regulators and networks in Acute myeloid leukemia, Related Products of tetrahydrofurans, the publication is Hematology (Abingdon, United Kingdom) (2019), 24(1), 487-491, database is CAplus and MEDLINE.

Acute myeloid leukemia (AML) is a heterogeneous and highly recurrent hematol. malignancy. Studies have shown an association between microRNAs and drive genes in AMLs. However, the regulatory roles of miRNAs in AML and how they act on downstream targets and the signaling pathway has been little studied. As to understand the mechanism of mRNA-miRNA interaction in the blood malignancy from a large scale of transcriptomic sequencing studies, we applied a comprehensive miRNA-mRNA association, co-expression gene network and ingenuity pathway anal. using TCGA AML datasets. Our results showed that his-mir-335 was a critical regulatory of homeobox A gene family. PBX3, KAT6A, MEIS1, and COMMD3-BMI1 were predicted as top transcription regulators in the regulatory network of the HOXA family. The most significantly enriched functions were cell growth, proliferation, and survival in the mRNA-miRNA network. Our work revealed that regulation of the HOXA gene family and its regulation played an important role in the development of AML.

Hematology (Abingdon, United Kingdom) published new progress about 1338466-77-5. 1338466-77-5 belongs to tetrahydrofurans, auxiliary class Epigenetics,Histone Methyltransferase, name is 1-(3-((((2R,3S,4R,5R)-5-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea, and the molecular formula is C10H16Br3N, Related Products of tetrahydrofurans.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Xuan, Maojie published the artcileC-S coupling with nitro group as leaving group via simple inorganic salt catalysis, Computed Properties of 57124-87-5, the publication is Chinese Chemical Letters (2020), 31(1), 84-90, database is CAplus.

An efficient and practical synthetic protocol to synthesize non-sym. aryl thioethers by nucleophilic aromatic substitution (S_NAr) reaction of nitroarenes by thiols with potassium phosphate as the catalyst is described. Various moderate to strong electron-withdrawing functional groups were tolerated by the system to provided thioethers in a good to excellent yields. The present method allowed access to 3 drug examples in a short reaction time. Finally, mechanistic studies suggested that the reaction may form the classic Meisenheimer complex through a two-step addition-elimination mechanism.

Chinese Chemical Letters published new progress about 57124-87-5. 57124-87-5 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Thiol, name is 2-Methyl-3-tetrahydrofuranthiol, and the molecular formula is C37H30ClIrOP2, Computed Properties of 57124-87-5.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Liu, Zhiwei published the artcileA proteomic and phosphoproteomic landscape of KRAS mutant cancers identifies combination therapies, Formula: C28H41N7O4, the publication is Molecular Cell (2021), 81(19), 4076-4090.e8, database is CAplus and MEDLINE.

KRAS mutant cancer, characterized by the activation of a plethora of phosphorylation signaling pathways, remains a major challenge for cancer therapy. Despite recent advancements, a comprehensive profile of the proteome and phosphoproteome is lacking. This study provides a proteomic and phosphoproteomic landscape of 43 KRAS mutant cancer cell lines across different tissue origins. By integrating transcriptomics, proteomics, and phosphoproteomics, we identify three subsets with distinct biol., clin., and therapeutic characteristics. The integrative anal. of phosphoproteome and drug sensitivity information facilitates the identification of a set of drug combinations with therapeutic potentials. Among them, we demonstrate that the combination of DOT1L and SHP2 inhibitors is an effective treatment specific for subset 2 of KRAS mutant cancers, corresponding to a set of TCGA clin. tumors with the poorest prognosis. Together, this study provides a resource to better understand KRAS mutant cancer heterogeneity and identify new therapeutic possibilities.

Molecular Cell published new progress about 1338466-77-5. 1338466-77-5 belongs to tetrahydrofurans, auxiliary class Epigenetics,Histone Methyltransferase, name is 1-(3-((((2R,3S,4R,5R)-5-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea, and the molecular formula is C28H41N7O4, Formula: C28H41N7O4.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Li, Xuepeng published the artcileCombined ultrasound and heat pretreatment improve the enzymatic hydrolysis of clam (Aloididae aloidi) and the flavor of hydrolysates, Category: tetrahydrofurans, the publication is Innovative Food Science & Emerging Technologies (2021), 102596, database is CAplus.

The effects of pretreatments with ultrasound (UP), heat (HP), and combinations of heat-ultrasound (HP-UP) and ultrasound-heat (UP-HP) on the flesh enzymolysis of clam (Aloididae aloidi) and the flavor characteristics of hydrolyzates were investigated. The optimum UP pretreatment conditions for the hydrolysis were obtained at ultrasound power of 500 W, ultrasound time of 20 min, and liquid/solid (L/S) ratio of 2:1 (v/w), yielded 41.33% of hydrolysis degree (DH). Among the different pretreatments, the UP pretreatment had the highest DH value, while the HP-UP pretreatment obtained the highest soluble peptide content. The UP pretreatment efficiently enhanced the contents of taste-active components, including free amino acids, 5′-nucleotides, and succinic acid. The HP pretreatment promoted the formation of pleasant volatile compounds and reduced the content of unpleasant volatile compounds, such as 1-octen-3-ol and 2-ethyl-1-hexanol. The combined HP-UP pretreatment was an effective method for improving the enzymic hydrolysis of clam and the flavor of hydrolyzate.

Innovative Food Science & Emerging Technologies published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Category: tetrahydrofurans.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Zhou, Zhilei published the artcileElucidation of the aroma compositions of Zhenjiang aromatic vinegar using comprehensive two dimensional gas chromatography coupled to time-of-flight mass spectrometry and gas chromatography-olfactometry, Synthetic Route of 19444-84-9, the publication is Journal of Chromatography A (2017), 218-226, database is CAplus and MEDLINE.

In this work, a method to characterize the aroma compounds of Zhenjiang aromatic vinegar (ZAV) was developed using comprehensive two dimensional gas chromatog. (GC × GC) coupled with time-of-flight mass spectrometry (TOFMS) and gas chromatog. olfactometry (GC-O). The column combination was optimized and good separation was achieved. Structured chromatograms of furans and pyrazines were obtained and discussed. A total of 360 compounds were tentatively identified based on mass spectrum match factors, structured chromatogram and linear retention indexes comparison. The most abundant class in number was ketones. A large number of esters, furans and derivatives, aldehydes and alcs. were also detected. The odor-active components were identified by comparison of the reported odor of the identified compounds with the odor of corresponding GC-O region. The odorants of methanethiol, 2-methyl-propanal, 2-methyl-butanal/3-methyl-butanal, octanal, 1-octen-3-one, di-Me trisulfide, trimethyl-pyrazine, acetic acid, 3-(methylthio)-propanal, furfural, benzeneacetaldehyde, 3-methyl-butanoic acid/2-methyl-butanoic acid and phenethyl acetate were suspected to be the most potent. About half of them were identified as significant aroma constituents in ZAV for the first time. Their contribution to specific sensory attribute of ZAJ was also studied. The results indicated that the presented method is suitable for characterization of ZAV aroma constituents. This study also enriches our knowledge on the components and aroma of ZAV.

Journal of Chromatography A published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C22H18O2, Synthetic Route of 19444-84-9.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Li, Qingyin published the artcileCo-hydrothermal carbonization of swine manure and cellulose: Influence of mutual interaction of intermediates on properties of the products, Application of 3-Hydroxydihydrofuran-2(3H)-one, the publication is Science of the Total Environment (2021), 148134, database is CAplus and MEDLINE.

Co-hydrothermal carbonization (HTC) of livestock manure and biomass might improve the fuel properties of the hydrochar due to the high reactivity of the biomass-derived intermediates with the abundant oxygen-containing functionalities. However, the complicated compositions make it difficult to explicit the specific roles of the individual components of biomass played in the co-HTC process. In this study, cellulose was used for co-HTC with swine manure to investigate the influence on the properties of the hydrochar. The yield of hydrochar obtained from co-HTC reduced gradually with the cellulose proportion increased, and the solid yield was lower than the theor. value. This was because the cellulose-derived intermediates favored the stability of the fragments from hydrolysis of swine manure. The increased temperature resulted in the reduction of the hydrochar yield whereas the prolonged time enhanced the formation of solid product. The interaction of the co-HTC intermediates facilitated the formation of O-containing species, thus making the solid more oxygen- and hydrogen-rich with a higher volatility. In addition, the co-HTC affected the evolution of functionalities like -OH and C=O during the thermal treatment of the hydrochar and altered its morphol. by stuffing the pores from swine manure-derived solid with the microspheres from HTC of cellulose. The interaction of the varied intermediates also impacted the formation of amines, ketones, carboxylic acids, esters, aromatics and the polymeric products in distinct ways.

Science of the Total Environment published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Application of 3-Hydroxydihydrofuran-2(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Wu, Haijun published the artcilePromoting the conversion of poplar to bio-oil based on the synergistic effect of alkaline hydrogen peroxide, Computed Properties of 19444-84-9, the publication is Renewable Energy (2022), 107-117, database is CAplus.

The synergistic catalysis effect of NaOH and H₂O₂ on the hydrothermal liquefaction (HTL) of poplar was investigated and compared to the NaOH or H₂O₂ catalyzed HTL at different temperatures and 30 min residence time. GC-MS, GPC, FT-IR, HPLC and TGA were used to comprehensively characterize the phys. and chem. properties of liquefied products (bio-oil, lignin and solid residue). The results showed that the highest total bio-oil yield (70.65%) was obtained at 280°C with NaOH (35 g/L)/H₂O₂ (30 g/L) as catalysts. The average mol. weight and polydispersity index (PDI) were found to be lower compared to that from other conditions. As the NaOH concentration was increased, the bio-oil yield was improved. The concentration of H₂O₂ for the optimal synergistic effect was observed to be 30 g/L. GC-MS anal. showed that the bio-oil obtained by NaOH (35 g/L)/H₂O₂ (30 g/L) was characterized with the lowest N content. The synergistic effect promoted the higher production selectivity of o-xylene and p-xylene in the bio-oil.

Renewable Energy published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C7H11N, Computed Properties of 19444-84-9.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Remon, Javier published the artcileToward Renewable-Based, Food-Applicable Prebiotics from Biomass: A One-Step, Additive-Free, Microwave-Assisted Hydrothermal Process for the Production of High Purity Xylo-oligosaccharides from Beech Wood Hemicellulose, Synthetic Route of 19444-84-9, the publication is ACS Sustainable Chemistry & Engineering (2019), 7(19), 16160-16172, database is CAplus.

Xylooligosaccharides (XOS) produced from biomass offer a plethora of excellent physicochem. and physiol. properties to be used as natural prebiotic nutraceuticals. Herein, this work first addresses and optimizes a novel one-pot, additive-free, microwave-assisted process to produce high purity XOS from beech wood hemicellulose, studying the influence of the temperature, reaction time, and solid loading. These variables exerted a significant influence, allowing the transformation of hemicellulose into a gas (0-19%), an XOS-rich liquid product (9-80%) and a spent solid material (17-90%). The liquid phase consisted of a mixture of XOS with a d.p. (DP) DP > 6 (75-100 C-weight %) and DP 3-6 (0-10 C-weight %), together with mono/disaccharides (0-1 C-weight %), carboxylic acids (0-5 C-weight %), ketones (0-12 C-weight %) and furans (0-12 C-weight %). A good compromise between the liquid yield (81%) and XOS purity (96 C-weight %) was achieved at 172 °C using a solid loading of 5 weight % for 47 min. This time could be reduced (33 min) and the solid loading increased (25 weight %) without substantially altering the XOS (98 C-weight %) purity, although the liquid yield was reduced. The liquid yield could be increased up to 97% at the expenses of XOS purity (90 C-weight %) at 177 °C using a 5 weight % solid loading for 60 min. For these optima, the microwave production costs shifted between 1.42 and 6.50 euro/kg XOS, which is substantially lower than the XOS market price, thus highlighting the high potential of this emerging technol. Novel microwave-assisted hydrothermal process assessed and optimized for the production of food-applicable prebiotic nutraceuticals from beech wood hemicellulose.

ACS Sustainable Chemistry & Engineering published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Synthetic Route of 19444-84-9.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem