Day: November 21, 2022

Torres-Pacheco, Luis J. published the artcileSorbitol electro-oxidation reaction on sub<10 nm PtAu bimetallic nanoparticles, Quality Control of 19444-84-9, the publication is Electrochimica Acta (2020), 136593, database is CAplus.

Sorbitol is a highly available and functionalized polyalc., with vast industrial usages and with great potential for fuel cells application. However, few studies were done regarding its electrochem. oxidation Monometallic Au, Pt and PtAu with different compositions from Pt-rich (such as Pt₈₅Au₁₅) to Au-rich (Pt₁₀Au₉₀) nanomaterials were synthesized. Several parameters like sorbitol and KOH concentration, scan rate, charge-transfer resistance, and temperature were tested. According with the physicochem. characterization, average particle sizes from 5.6 to 6.5 nm were found for all electrocatalysts, while Pt at. percentages of 85, 60, 40, and 10% were obtained. XPS revealed shifts in Pt 4f and Au 4f core-levels related to electron d. changes by the interaction between these elements and as a result, the electrocatalytic properties for the sorbitol electrooxidation reaction (SOR) were modified. The PtAu nanomaterials presented an increase of the c.d. with the raise of the KOH and sorbitol concentrations, being Pt₄₀Au₆₀/C the most active electrocatalyst displaying 40 mA mg^-1 at 0.1M sorbitol in 2 M KOH with an onset potential of -0.50 V vs. normal H electrode. This onset potential value was more neg. to that typically reported for other polyols like glycerol and ethylene glycol. The reaction pathway of Pt/C, Au/C and Pt₄₀Au₆₀/C was followed by chromatog. and spectroscopic techniques, finding that the complex surfaces of these electrocatalysts were capable to carry the SOR via several electrons (from 2 to 24 e^–). In this manner, the high electrocatalytic activity of Pt₄₀Au₆₀/C was attributed to the electron d. changes that promote a higher electron transfer forming shorter-chain byproducts.

Electrochimica Acta published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C16H24BF4Ir, Quality Control of 19444-84-9.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Ozpinar, H. published the artcileAlleophatic effects of benzoic acid, salicylic acid and leaf extract of Persica vulgaris Mill. (Rosaceae), COA of Formula: C4H6O3, the publication is South African Journal of Botany (2017), 102-109, database is CAplus.

Secondary compounds in higher plants have great diversity in terms of biol. activity. Most of them are used for the defense by plants. This study aims to investigate the effects of benzoic acid, salicylic acid, and Persica vulgaris Mill. (Peach) on the germination of the seeds of cultivated plants such as Triticum aestivum L. (wheat), Zea mays L. (corn), Cicer arietinum L. (chickpea), as well as weeds such as Lepidium campestre (L.) R.Br. and Convolvulus arvensis L. Method 1, in which benzoic acid, salicylic acid, and Persica vulgaris Mill. are added to the germination environment at different doses, and Method 2, in which they are mixed with the irrigation water at the specified doses, have been employed in this study. As a result of this study, it has been determined that the leaf extract of P. vulgaris Mill., Benzoic acid, and salicylic acid prevent the growth of the root and stem in all seeds at high doses in both methods, and they increase the growth at low doses. According to the GC-MS results of the leaf extract of P. vulgaris Mill., benzoic acid has been determined to be at the highest rate. No difference has been found between months as a result of the HPLC anal. of the amounts of benzoic acid. The determination of neg. effects of benzoic acid, salicylic acid, and peach leaf extract both on cultivated plants and weeds at high doses will repress the development of cultivated plants as well as weeds. Growing cultivated plants in places with peach trees may decrease the yield. The leaves should not be let decompose on the soil in defoliation season, and fallen leaves should be collected. Not collecting all of the leaves and leaving some of them may increase the development of weeds in the surrounding area since it may cause a low dose effect.

South African Journal of Botany published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, COA of Formula: C4H6O3.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Wurzler, Gleicielle Tozzi published the artcileIntegrating bio-oil and carbohydrate valorization on the fractionation of sugarcane bagasse via Organosolv process using Mo₂C-based catalysts, Safety of 3-Hydroxydihydrofuran-2(3H)-one, the publication is Fuel Processing Technology (2022), 107208, database is CAplus.

This work studied the fractionation of sugarcane bagasse via Organosolv treatment using isopropanol/water in the presence of Raney-Ni and molybdenum carbide catalysts (Bulk Mo₂C and Mo2C supported on activated carbon (AC) or Al₂O₃). The degree of delignification, the bio-oil and solid residue composition depended on the type of catalyst. A partial extraction of hemicellulose occurred followed by depolymerization, resulting in a product distribution that depended on the catalyst. Raney-Ni catalyst promoted the formation of diols and triols, while xylose, furfural, and furan were mainly produced by Mo₂C based-catalysts. The Organosolv treatment without catalyst and in the presence of bulk Mo₂C produced a bio-oil containing mainly 2,3-dihydrobenzofuran. Mo₂C/AC and Mo₂C/Al₂O₃ are promising catalysts for the fractionation of sugarcane bagasse that produced a bio-oil with higher yield to substituted methoxyphenols and a solid residue more easily hydrolyzed by cellulases, producing higher yield to glucose than Raney-Ni catalyst.

Fuel Processing Technology published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C10H10N2, Safety of 3-Hydroxydihydrofuran-2(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Silveira, Marcello R. published the artcileGuava-flavored whey beverage processed by cold plasma technology: Bioactive compounds, fatty acid profile and volatile compounds, Quality Control of 19444-84-9, the publication is Food Chemistry (2019), 120-127, database is CAplus and MEDLINE.

The effect of cold plasma processing time and gas flow on bioactive compounds such as vitamin C, carotenoids and phenolic compounds, DPPH, angiotensin-converting-enzyme (ACE) inhibitory activity, fatty acids profile, and volatile compounds of guava-flavored whey beverage was investigated. For comparative purposes, a pasteurized beverage was also manufactured Cold plasma increased the concentration of bioactive and volatile compounds, and proportionated changes in the fatty acids profile. The milder conditions like lower flow rate and processing time, resulted in higher vitamin C and volatile compounds levels, and higher antioxidant activity, but with a lower carotenoids content and a less favorable fatty acids profile. More drastic conditions like higher flow rate and processing time resulted in products with lower vitamin C and volatile compounds levels, but with higher carotenoids content and ACE inhibitory activity. It can be concluded that the cold plasma processing can improve the properties of the guava-flavored whey beverages (increased concentration of bioactive and volatile compounds), while the effect on the fatty acid profile and ACE inhibitory activity is dependent on the process parameters (processing time and flow rate).

Food Chemistry published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C10H16Br3N, Quality Control of 19444-84-9.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Braun, Theodore P. published the artcileCombined inhibition of JAK/STAT pathway and lysine-specific demethylase 1 as a therapeutic strategy in CSF3R/CEBPA mutant acute myeloid leukemia, Related Products of tetrahydrofurans, the publication is Proceedings of the National Academy of Sciences of the United States of America (2020), 117(24), 13670-13679, database is CAplus and MEDLINE.

Acute myeloid leukemia (AML) is a deadly hematol. malignancy with poor prognosis, particularly in the elderly. Even among individuals with favorable-risk disease, approx. half will relapse with conventional therapy. In this clin. circumstance, the determinants of relapse are unclear, and there are no therapeutic interventions that can prevent recurrent disease. Mutations in the transcription factor CEBPA are associated with favorable risk in AML. However, mutations in the growth factor receptor CSF3R are commonly co-occurrent in CEBPA mutant AML and are associated with an increased risk of relapse. To develop therapeutic strategies for this disease subset, we performed medium-throughput drug screening on CEBPA/CSF3R mutant leukemia cells and identified sensitivity to inhibitors of lysine-specific demethylase 1 (LSD1). Treatment of CSF3R/CEBPA mutant leukemia cells with LSD1 inhibitors reactivates differentiation-associated enhancers driving immunophenotypic and morphol. differentiation. LSD1 inhibition is ineffective as monotherapy but demonstrates synergy with inhibitors of JAK/STAT signaling, doubling median survival in vivo. These results demonstrate that combined inhibition of JAK/STAT signaling and LSD1 is a promising therapeutic strategy for CEBPA/CSF3R mutant AML.

Proceedings of the National Academy of Sciences of the United States of America published new progress about 1338466-77-5. 1338466-77-5 belongs to tetrahydrofurans, auxiliary class Epigenetics,Histone Methyltransferase, name is 1-(3-((((2R,3S,4R,5R)-5-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea, and the molecular formula is C28H41N7O4, Related Products of tetrahydrofurans.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Spanik, Ivan published the artcileClassification of wine distillates using multivariate statistical methods based on their direct GC-MS analysis, Recommanded Product: 3-Hydroxydihydrofuran-2(3H)-one, the publication is Chemical Papers (2015), 69(3), 395-401, database is CAplus.

This work describes a novel methodol. for the recognition of brandies based on direct injection of a raw sample followed by GC-MS anal. Direct injection was chosen for its simplicity and the fact that the composition of the samples analyzed remains unchanged compared to original brandy. The repeatability of the anal. procedure was evaluated by a comparison of the peak areas for randomly selected compounds obtained from 10 parallel measurements. A novel chemometric procedure was investigated in order to sep. the samples studied on the basis of their geog. origin, processing technol. or maturation time. In this procedure, a principal component anal. was applied to full chromatograms to select the time interval that shows the significant differences between the samples studied. It was shown that the chromatogram recorded at 36-39 min bore the maximal differences, hence it could be used to classify the brandy samples. The chromatog. peaks found within this time interval were identified and their peak areas determined These compounds could be used as specific markers for determining geog. origin or processing technol.

Chemical Papers published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C8H17Br, Recommanded Product: 3-Hydroxydihydrofuran-2(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Condurso, Concetta published the artcileStability of powdered infant formula during secondary shelf-life and domestic practices, SDS of cas: 19444-84-9, the publication is International Dairy Journal (2020), 104761, database is CAplus.

Powd. infant formula (PIF) and lactose-free PIF during secondary shelf-life (SSL) and under domestic practices was investigated to verify their stability up to the expiration date and under the label instructions for milk reconstitution. Particular attention was given to variations in Maillard reaction and lipid peroxidation products identified and quantified by HS-SPME-GC-MS. Two types of PIF: Type A based on bovine milk and Type B a lactose-free product based on glucose syrup were analyzed. The PIF were analyzed at regular time intervals beyond the labeled expiration date after opening, and reconstituted using water at 70°C, 80°C and 90°C. A large number of volatile compounds were identified and significant statistically differences resulted during SSL and water temperature used for reconstitution that were correlated to the PIF composition The study showed that water temperature for reconstitution of samples and the SSL has to be adapted to PIF composition

International Dairy Journal published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, SDS of cas: 19444-84-9.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Sarkaria, S. M. published the artcilePrimary acute myeloid leukemia cells with IDH1 or IDH2 mutations respond to a DOT1L inhibitor in vitro, Related Products of tetrahydrofurans, the publication is Leukemia (2014), 28(12), 2403-2406, database is CAplus and MEDLINE.

The aim was to test the effects of DOT1Linhibition against a set of cryopreserved, genomically characterized de novo AML patient samples, collected through a study approved by the Human Research Protection Office at Washington University School of Medicine after patients provided informed consent.

Leukemia published new progress about 1338466-77-5. 1338466-77-5 belongs to tetrahydrofurans, auxiliary class Epigenetics,Histone Methyltransferase, name is 1-(3-((((2R,3S,4R,5R)-5-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea, and the molecular formula is C28H41N7O4, Related Products of tetrahydrofurans.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Yu, Wenyu published the artcileCatalytic site remodelling of the DOT1L methyltransferase by selective inhibitors, Computed Properties of 1338466-77-5, the publication is Nature Communications (2012), 3(Dec.), 2304/1-2304/11, database is CAplus and MEDLINE.

Selective inhibition of protein methyltransferases is a promising new approach to drug discovery. An attractive strategy towards this goal is the development of compounds that selectively inhibit binding of the cofactor, S-adenosylmethionine, within specific protein methyltransferases. Here we report the three-dimensional structure of the protein methyltransferase DOT1L bound to EPZ004777, the first S-adenosylmethionine-competitive inhibitor of a protein methyltransferase with in vivo efficacy. This structure and those of four new analogs reveal remodelling of the catalytic site. EPZ004777 and a brominated analog, SGC0946, inhibit DOT1L in vitro and selectively kill mixed lineage leukemia cells, in which DOT1L is aberrantly localized via interaction with an oncogenic MLL fusion protein. These data provide important new insight into mechanisms of cell-active S-adenosylmethionine-competitive protein methyltransferase inhibitors, and establish a foundation for the further development of drug-like inhibitors of DOT1L for cancer therapy.

Nature Communications published new progress about 1338466-77-5. 1338466-77-5 belongs to tetrahydrofurans, auxiliary class Epigenetics,Histone Methyltransferase, name is 1-(3-((((2R,3S,4R,5R)-5-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea, and the molecular formula is C4H10O2, Computed Properties of 1338466-77-5.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Choi, Jae-Wook published the artcileFeasibility of Laminaria japonica as a feedstock for fast pyrolysis in a bubbling fluidized-bed reactor, Recommanded Product: 3-Hydroxydihydrofuran-2(3H)-one, the publication is Journal of Analytical and Applied Pyrolysis (2015), 141-149, database is CAplus.

Laminaria japonica, brown algae, was used as a feedstock for fast pyrolysis in a bubbling fluidized-bed (BFB) reactor by manipulating the pyrolysis temperature, feeding rate, and ratio of the fluidizing velocity to the min. fluidizing velocity (U/U_mf), which exhibited optimum operating conditions of a feeding rate of 600 g/h, a U/U_mf of 18.3 and a pyrolysis temperature of 425°C. The maximum yield of L. japonica-derived bio-oil (approx. 35 weight %) was lower than that of lignocellulose. When fractionated, the L. japonica-derived bio-oil was found to be composed of several major compounds, including cyclic aliphatic compounds, which were very different from aromatic mols., the major compounds of lignocellulose-derived bio-oil.

Journal of Analytical and Applied Pyrolysis published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Recommanded Product: 3-Hydroxydihydrofuran-2(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem