Day: November 21, 2022

Wang, Wenli published the artcileAnalysis of volatile compounds in Chinese dry-cured hams by comprehensive two-dimensional gas chromatography with high-resolution time-of-flight mass spectrometry, COA of Formula: C4H6O3, the publication is Meat Science (2018), 14-25, database is CAplus and MEDLINE.

A microwave assisted extraction method coupled with solvent assisted flavor evaporation (MAE-SAFE) was used to extract the volatiles from three-selected Chinese dry-cured hams (Jinhua ham, Xuanwei ham and Rugao ham). Extracts were analyzed by comprehensive two-dimensional gas chromatog. with high-resolution time-of-flight mass spectrometry (GC × GC/HR-TOFMS), gas chromatog.-mass spectrometry (GC-MS), resp. A total 165 volatile compounds were identified by GC × GC/HR-TOFMS while only 50 compounds were identified by GC-MS. Principal component anal. showed that the specific dominant volatile compounds were [S-(R*,R*)]-2,3-butanediol (26.39%) and 3-methyl-butanoic acid (7.53%) for Jinhua ham, were [R-(R*,R*)]-2,3-butanediol (16.85%) and acetic acid (8.25%) for Rugao ham and were dihydro-4-hydroxy-2(3H)-furanone (11.67%) and hexanoic acid (8.24%) for Xuanwei ham. The results not only provided a fast and mild extraction method to analyze the volatiles in non-volatile food matrixes, but also represented the detailed information of volatile profiles of Chinese dry-cured hams.

Meat Science published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C20H18BrN3, COA of Formula: C4H6O3.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Yi, Joanna S. published the artcileStructure-Guided DOT1L Probe Optimization by Label-Free Ligand Displacement, Safety of 1-(3-((((2R,3S,4R,5R)-5-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea, the publication is ACS Chemical Biology (2015), 10(3), 667-674, database is CAplus and MEDLINE.

The DOT1L lysine methyltransferase has emerged as a validated therapeutic target in MLL-rearranged (MLLr) acute leukemias. Although S-adenosylmethionine competitive inhibitors have demonstrated pharmacol. proof-of-principle in MLLr-leukemia, these compounds require further optimization to improve cellular potency and pharmacokinetic stability. Limiting DOT1L inhibitor discovery and ligand optimization have been complex biochem. methods often using radionucleotides and cellular methods requiring prolonged culture. The authors therefore developed a new suite of assay technologies that allows comparative assessment of chem. tools for DOT1L in a miniaturized format. Coupling these assays with structural information, the authors developed new insights into DOT1L ligand binding and identified several functionalized probes with increased cellular potency (IC₅₀ values ∼10 nM) and excellent selectivity for DOT1L. Together these assay technologies define a platform capability for discovery and optimization of small-mol. DOT1L inhibitors.

ACS Chemical Biology published new progress about 1338466-77-5. 1338466-77-5 belongs to tetrahydrofurans, auxiliary class Epigenetics,Histone Methyltransferase, name is 1-(3-((((2R,3S,4R,5R)-5-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea, and the molecular formula is C15H12O6, Safety of 1-(3-((((2R,3S,4R,5R)-5-(4-Amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Li, Xiaoman published the artcileCatalyst- and Metal-Free Photo-Oxidative Coupling of Thiols with BrCCl₃, HPLC of Formula: 57124-87-5, the publication is European Journal of Organic Chemistry (2022), 2022(23), e202200340, database is CAplus.

This paper reported a catalyst- and metal-free method to construct disulfide bond with BrCCl₃ under light irradiation This clean and mild reaction promoted the oxidative coupling of thiols with wide substrate scope, and was applicable to benzylic, aryl and aliphatic thiols, especially cysteine derivative The disulfides were obtained in high yields up to 98%, avoiding the use of heating, strong oxidant, metal reagent or catalyst. This facile strategy facilitated the synthesis of disulfide compounds

European Journal of Organic Chemistry published new progress about 57124-87-5. 57124-87-5 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Thiol, name is 2-Methyl-3-tetrahydrofuranthiol, and the molecular formula is C5H10OS, HPLC of Formula: 57124-87-5.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Savareear, Benjamin published the artcileNon-targeted analysis of the particulate phase of heated tobacco product aerosol and cigarette mainstream tobacco smoke by thermal desorption comprehensive two-dimensional gas chromatography with dual flame ionisation and mass spectrometric detection, Quality Control of 19444-84-9, the publication is Journal of Chromatography A (2019), 327-337, database is CAplus and MEDLINE.

An anal. methodol. based on thermal desorption and comprehensive two-dimensional gas chromatog. with dual time-of-flight mass spectrometry and flame ionization detection (TD-GC × GC-TOFMS/FID) was developed for non-target anal. of volatile organic compounds (VOCs). The technique was optimized for the measurement of the VOC content of the particulate phase (PP) fraction of aerosols produced by a tobacco heating product (THP1.0) and 3R4F mainstream tobacco smoke (MTS). The method involves sampling the PP fraction on quartz wool packed in a sorbent tube directly connected to machine-puffing, followed by a dilution through a TD recollection procedure over Tenax/Sulficarb sorbent before TD-GC × GC-TOFMS/FID anal. The comparison of the VOC content of the PP fraction of aerosols produced by THP1.0 and MTS highlighted the compositional difference between tobacco combustion (592 peaks) and tobacco heating process (160 peaks). Mass spectrometric signals were used for qual. analyses based on linear retention indexes, mass spectral matches, and GC × GC structured chromatograms, which collectively identified up to 90% of analytes detected in PP samples. FID signals were used for semi-quant. analyses based on a chem. class external calibration method. The global chem. composition of PP samples showed that hydrocarbons, oxygenated, and nitrogen-containing compounds were fewer in number and much less abundant in THP1.0 PP. Overall, 93 compounds were common to the two sample types. Excepted for a few highly volatile compounds (mainly furan family) as well as glycerin and its acetate, analyte concentrations were higher in MTS PP.

Journal of Chromatography A published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Quality Control of 19444-84-9.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Efimtseva, Ekaterina V. published the artcileSynthesis of disaccharide nucleosides and their incorporation into oligonucleotides, SDS of cas: 87865-78-9, the publication is Collection of Czechoslovak Chemical Communications (1996), 61(Spec. Issue), S206-S209, database is CAplus.

A high yield synthesis of 2′-O-ribofuranosyl nucleosides has been achieved and incorporation of the cytosine analog into oligonucleotides was accomplished without difficulties. The supplementary cis diol group thus present in the middle of an oligonucleotide could be easily converted to a reactive dialdehyde moiety.

Collection of Czechoslovak Chemical Communications published new progress about 87865-78-9. 87865-78-9 belongs to tetrahydrofurans, auxiliary class Nucleosides and Nucleotides,Nucleoside Analogues, name is N-(9-((6aR,8R,9R,9aS)-9-Hydroxy-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide, and the molecular formula is C26H45N5O7Si2, SDS of cas: 87865-78-9.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Eltayeb, Ikram Mohamed published the artcileComparative study of chemical composition of Acacia seyal stem, stem wood and stem bark dry distillates used by sudaneses women as cosmetic and medicine, Synthetic Route of 19444-84-9, the publication is International Journal of Pharmacy and Pharmaceutical Sciences (2017), 9(11), 218-224, database is CAplus.

The content and chem. composition of dry distillates of the stem, stem wood and stem bark of Acacia seyal were investigated. The distillates are fumigants of A. seyal locally known in Sudan as Dokhan and widely used for its cosmetic, aromatic and medicinal value for the treatment of candidiasis, genital yeast infection, urinary tract infection, diarrhoea, respiratory tract infection, skin infection and with potent, antioxidant and antimicrobial activities. The dry distillates were prepared by dry distillation method from the Acacia seyal stem, stem wood and stem bark and investigated chem. by GC-MS anal. GC-MS anal. revealed the presence of one hundred and 23 constituents in the stem distillate with major constituents of solerone, furfural, catechol, syringol, allo-inositol, mequinol, furfuralc., 3-methyl-1,2-cyclopentanedione, phenol, homovanillyl alc. and 3-cresol. the wood distillate show detection of eighty compounds, with main 1, 3-dimethyl-5-methoxypyrazol, syringol, furfuralc., mequinol, 1,2-anhydro-3,4,5,6-alloinositol, 3-methyl-1,2-cyclopentanedione, catechol, 3-methoxycatechol, homovanillyl alc., homosyringic acid, 3-cresol, 3-methyl-2-cyclopentenone and 1,2-cyclopentanedione. Sixty six compounds were detected in the distillate bark and the main compounds were found to be hexadecanoic, catechol, tetrapentacontane, phenol, mequinol and 2-ethylfurane. The result concludes that the medicinal Sudanese Dokhan have good potential as sources of different bioactive compounds and antioxidants.

International Journal of Pharmacy and Pharmaceutical Sciences published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Synthetic Route of 19444-84-9.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Mikhailov, Sergey N. published the artcileAn efficient synthesis and physico-chemical properties of 2′-O-D-ribofuranosylnucleosides, minor tRNA components, Recommanded Product: N-(9-((6aR,8R,9R,9aS)-9-Hydroxy-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide, the publication is Journal of Carbohydrate Chemistry (1997), 16(1), 75-92, database is CAplus.

A high yield preparation of 9-(2-O-β-D-ribofuranosyl-β-D-ribofuranosyl)adenine, guanine- and the pyrimidine analogs (cytosine, thymine and uracil base moiety) has been achieved, and the conformational properties of the ring systems were investigated using NMR spectroscopy and X-ray. Title compounds did not show any antiviral activity.

Journal of Carbohydrate Chemistry published new progress about 87865-78-9. 87865-78-9 belongs to tetrahydrofurans, auxiliary class Nucleosides and Nucleotides,Nucleoside Analogues, name is N-(9-((6aR,8R,9R,9aS)-9-Hydroxy-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide, and the molecular formula is C26H45N5O7Si2, Recommanded Product: N-(9-((6aR,8R,9R,9aS)-9-Hydroxy-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Ali, Khursheed published the artcileAloe vera extract functionalized zinc oxide nanoparticles as nanoantibiotics against multi-drug resistant clinical bacterial isolates, Recommanded Product: 3-Hydroxydihydrofuran-2(3H)-one, the publication is Journal of Colloid and Interface Science (2016), 145-156, database is CAplus and MEDLINE.

ZnO nanoparticles (ZnONPs) were synthesized through a simple and efficient biogenic synthesis approach, exploiting the reducing and capping potential of Aloe barbadensis Miller (A. vera) leaf extract (ALE). ALE-capped ZnO nanoparticles (ALE-ZnONPs) were characterized using UV-Vis spectroscopy, x-ray diffraction (x-ray diffraction), Fourier transform IR (FTIR) spectroscopy, SEM, energy dispersive x-ray spectroscopy (EDX), and TEM analyses. X-ray diffraction anal. provided the average size of ZnONPs as 15 nm. FTIR spectral anal. suggested the role of phenolic compounds, terpenoids and proteins present in ALE, in nucleation and stability of ZnONPs. Flow cytometry and at. absorption spectrophotometry (AAS) data analyses revealed the surface binding and internalization of ZnONPs in Gram +ve (Staphylococcus aureus) and Gram -ve (Escherichia coli) cells, resp. Significant antibacterial activity of ALE-ZnONPs was observed against extended spectrum beta lactamases (ESBL) pos. E. coli, Pseudomonas aeruginosa, and methicillin resistant S. aureus (MRSA) clin. isolates exhibiting the MIC and MBC values of 2200, 2400 μg/mL and 2300, 2700 μg/mL, resp. Substantial inhibitory effects of ALE-ZnONPs on bacterial growth kinetics, exopolysaccharides and biofilm formation, unequivocally suggested the antibiotic and antibiofilm potential. Overall, the results elucidated a rapid, environmentally benign, cost-effective, and convenient method for ALE-ZnONPs synthesis, for possible applications as nanoantibiotics or drug carriers.

Journal of Colloid and Interface Science published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Recommanded Product: 3-Hydroxydihydrofuran-2(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

De Clercq, Rik published the artcileConfinement Effects in Lewis Acid-Catalyzed Sugar Conversion: Steering Toward Functional Polyester Building Blocks, Category: tetrahydrofurans, the publication is ACS Catalysis (2015), 5(10), 5803-5811, database is CAplus.

We report the use of solid Lewis acid catalysts for the conversion of tetrose sugars to four-carbon α-hydroxy acid esters (C₄-AHA), which are useful as functional polyester building blocks. Sn-β was by far the most active and selective catalyst, yielding up to 80% Me vinyl glycolate (MVG), methyl-4-methoxy-2-hydroxybutanoate (MMHB), and α-hydroxy-γ-butyrolactone (HBL) combined at 95% conversion. A very high turnover frequency (TOF) of 330 mol_C4-AHA mol_Sn h^-1 was attained using Sn-β, a more than 6-fold increase compared with homogeneous SnCl₄·5H₂O. It is shown that, using different Sn-based catalysts with various pore sizes, the product distribution is strongly dependent on the size of the catalyst pores. Catalysts containing mainly mesopores, such as Sn-MCM-41 or Sn-SBA-15, prefer the production of the more bulky MMHB, whereas microporous catalysts such as Sn-β or Sn-MFI favor the production of MVG. This effect can be further enhanced by increasing the reaction temperature At 363 K, only 20% MVG is attained using Sn-β, but at 433 K, this increases to 50%. Using a kinetic anal., it was found that, in microporous catalysts, steric hindrance near the Sn active site in the catalyst pores plays a dominant role in favoring the reaction pathway toward MVG. Moreover, the selectivity toward both products is kinetically controlled.

ACS Catalysis published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Category: tetrahydrofurans.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Rao, T. Sudhakar published the artcileSynthesis of oligodeoxyribonucleotides containing 7-(2-deoxy-β-D-erythro-pentofuranosyl)guanine and 8-amino-2′-deoxyguanosine, Category: tetrahydrofurans, the publication is Journal of Heterocyclic Chemistry (1994), 31(4), 935-40, database is CAplus.

Merrifield synthesis of (deoxy-D-erythro-pentofuranosyl)guanine and aminodeoxyguanosine-containing oligodeoxyribonucleotide triplexes via key intermediate phosphoramidites I (B = R, R¹)is reported.

Journal of Heterocyclic Chemistry published new progress about 87865-78-9. 87865-78-9 belongs to tetrahydrofurans, auxiliary class Nucleosides and Nucleotides,Nucleoside Analogues, name is N-(9-((6aR,8R,9R,9aS)-9-Hydroxy-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide, and the molecular formula is C26H45N5O7Si2, Category: tetrahydrofurans.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem