Day: November 21, 2022

Takaku, Hiroshi published the artcileSynthesis of oligoribonucleotides by using 2′-O-(1-methyl-1-methoxy)ethyl nucleosides, HPLC of Formula: 87865-78-9, the publication is Chemistry Letters (1987), 1787-90, database is CAplus.

3′,5′-O-Tetraisopropyldisiloxanylnucleosides I (R = benzoyladenine, uridine, R¹ = H) smoothly react with 2-methoxypropene to give I [R¹ = C(OMe)Me₂] in high yields without formation of diastereoisomers. These nucleosides were used as intermediates for oligonucleotide synthesis by the phosphotriester method. The (1-methyl-1-methoxy)ethyl group was removed rapidly from oligonucleotides by acid treatment.

Chemistry Letters published new progress about 87865-78-9. 87865-78-9 belongs to tetrahydrofurans, auxiliary class Nucleosides and Nucleotides,Nucleoside Analogues, name is N-(9-((6aR,8R,9R,9aS)-9-Hydroxy-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide, and the molecular formula is C12H9N3O4, HPLC of Formula: 87865-78-9.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

James-Okoro, Paula-Peace O. published the artcilePhytochemical and in vitro antioxidant assessment of Yoyo bitters, Formula: C4H6O3, the publication is World News of Natural Sciences (2021), 1-17, database is CAplus.

In this paper, herbal bitters are widely used due to their numerous acclaimed health benefits in many Nigerian homes; however, many have not been subjected to scientific scrutiny. The aim of this study was to determine the phytochem. composition and antioxidant capacity of a non-alc. polyherbal formulation, Yoyo bitters, towards validating its broad pharmacol. claims. The phytochem. components of Yoyo bitters were ascertained by phytochem. screening assays and gas chromatog.-mass spectrometry (GC-MS). The antioxidant activity was investigated in vitro using 2,2-diphenyl-1-picryhydrazyl (DPPH) radical, hydrogen peroxide (H₂O₂) scavenging activity, total antioxidant capacity (TAC) and ferric reducing antioxidant power (FRAP) assays. Qual. phytochem. anal. of Yoyo bitters showed the presence of saponins, tannins, flavonoids, terpenoids, cardiac glycosides and anthocyanins. The total phenols, flavonoids, flavanols, tannins and carotenoids content were 14.741 ± 0.64 mg GAE/mL, 0.152 ± 0.01 mg RE/mL, 0.437 ± 0.02 mg RE/mL, 0.368 ± 0.04 mg TAE/mL and 0.016 ± 0.00 mg CAE/mL resp. GC-MS chromatogram revealed the presence of forty-three (43) phytochem. compounds with D-allose (41.81%), 1,6-anhydro-beta-D-glucofuranose (24.15%), 5-hydroxymethylfurfural (8.02%) and Z-6-pentadecen-1-ol acetate (3.50%) as the most abundant constituents. Yoyo bitters demonstrated effective antioxidant activity against DPPH and H₂O₂ with IC₅₀ values of 0.492 mg/mL and 0.629 mg/mL resp. compared to ascorbic acid of 0.161 mg/mL and 0.130 mg/mL resp. Total antioxidant capacity and ferric reducing antioxidant power of Yoyo bitters were 0.432 mg AAE/mL and 2.236 mg AAE/mL resp. This study validates the antioxidant capacity of Yoyo bitters and provides chem. basis for its acclaimed pharmacol. actions.

World News of Natural Sciences published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Formula: C4H6O3.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Xu, Huan published the artcileStereocontrolled Entanglement-Directed Self-Alignment of Poly(lactic acid) Cylindrites, Category: tetrahydrofurans, the publication is Macromolecular Chemistry and Physics (2016), 217(23), 2567-2575, database is CAplus.

The concept of stereocontrolled entanglements, in which the tunable H-bonded chiral pairs serve as crosslinks to create topol. constraints on the local chain dynamics, is introduced to tailor the crystalline morphol. of stereocomplex poly(lactic acid). For the entanglements to be interconnected and activated, poly(D-lactic acid) with statistical branched architecture is incorporated, enabling the construction of 3D association with linear poly(L-lactic acid) chains. With thermodynamically graded disentanglement relaxation for the blends, the profound influence of entanglements on the crystalline morphol. is revealed during isothermal crystallization Orderly aligned cylindrites some with an exceptional length of over 500 μm, resembling the structural features of the classical shish-kebab superstructure, are observed in the blends penetrated with dense entanglement constraints. By contrast, only dendritic spherulites are formed in the highly disentangled blends. The selectively suppressed homo-crystallization by the entanglements offers insights into the contribution of constraints. This bottom-up strategy opens up pathways to engender oriented crystals of long-range order under quiescent conditions, which has potential implications for other chiral polymers.

Macromolecular Chemistry and Physics published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C15H14O, Category: tetrahydrofurans.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Ogawa, Takashi published the artcileSolid-phase synthesis of oligoribonucleotides using 5′-9-fluorenylmethoxycarbonyl and 2′-1-(isopropoxyl)ethyl protection, Synthetic Route of 87865-78-9, the publication is Chemistry Letters (1991), 1169-72, database is CAplus.

The 1-(isopropoxy)ethyl group has been employed for the protection of the 2′-hydroxy groups of ribonucleoside residues in the synthesis of oligoribonucleotides by the phosphoramidite approach on a solid support, using a base-labile 5′-9-fluorenylmethoxycarbonyl group.

Chemistry Letters published new progress about 87865-78-9. 87865-78-9 belongs to tetrahydrofurans, auxiliary class Nucleosides and Nucleotides,Nucleoside Analogues, name is N-(9-((6aR,8R,9R,9aS)-9-Hydroxy-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide, and the molecular formula is C26H45N5O7Si2, Synthetic Route of 87865-78-9.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Timoshchuk, Victor A. published the artcileImproved and Reliable Synthesis of 3′-Azido-2′,3′-dideoxyguanosine Derivatives, COA of Formula: C26H45N5O7Si2, the publication is Nucleosides, Nucleotides & Nucleic Acids (2004), 23(1 & 2), 171-181, database is CAplus and MEDLINE.

An improved synthesis of N²-protected-3′-azido-2′,3′-dideoxyguanosine is described. Deoxygenation of 2′-O-alkyl (and/or aryl) sulfonyl-5′-dimethoxytritylguanosine coupled with [1,2]-hydride shift rearrangement gave protected 9-(2-deoxythreo-pentofuranosyl)guanines. This rearrangement was accomplished in high yield with a high degree of stereoselectivity using lithium triisobutylborohydride (L-Selectride). The resulting 2-deoxythreo-pentofuranosyl derivatives were transformed into 3′-O-mesylates, which can be used for 3′-substitution. The 3′-azido nucleosides were obtained by treatment of the 3′-O-mesylates with lithium azide. This procedure is reproducible with a good overall yield.

Nucleosides, Nucleotides & Nucleic Acids published new progress about 87865-78-9. 87865-78-9 belongs to tetrahydrofurans, auxiliary class Nucleosides and Nucleotides,Nucleoside Analogues, name is N-(9-((6aR,8R,9R,9aS)-9-Hydroxy-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide, and the molecular formula is C17H18N2O6, COA of Formula: C26H45N5O7Si2.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Groenewold, Gary S. published the artcileSignatures of Biologically Driven Hemicellulose Modification Quantified by Analytical Pyrolysis Coupled with Multidimensional Gas Chromatography Mass Spectrometry, Safety of 3-Hydroxydihydrofuran-2(3H)-one, the publication is ACS Sustainable Chemistry & Engineering (2020), 8(4), 1989-1997, database is CAplus.

Biomass storage conditions are a major source of feedstock quality variability that impact downstream preprocessing, feeding, handling and conversion into biofuels, chems. and products. Microbial activity in the stored biomass can result in heating that can modify or degrade the cell walls of the biomass, changing its characteristics. Anal. pyrolysis has been used to characterize biomass, but at temperatures typically used (∼600°C), differentiation of samples having different storage histories is subtle or non-existent. In this study, lower-temperature (400°C) pyrolysis was used to show large differences in corn stover samples that had experienced different biol. heating histories, indicated by pyrolysis products that were identified, and in several cases quantified using two-dimensional gas chromatog. / mass spectrometry. Pyrolysis of the samples originating from biomass that had experienced biol. heating during storage generated small oxygenates such as furfural, 5-Me furfural and 2-(5H)-furanone with efficiencies that were as much as ten times greater than those measured for samples that were not significantly heated. Most of the pyrolysis products with enhanced efficiencies were C5 oxygenates, suggesting formation from hemicellulosic precursor polymers in the corn stover. The findings suggest that biol. heating is disrupting the cell wall structure, fragmenting the hemicellulose or cellulose chains, and generating more polymer termini that have higher efficiency for generating the oxygenates at lower temperatures Further, anal. pyrolysis conducted at lower temperatures may be a beneficial strategy for improved biomass cell wall characterization, and for providing insights to understand and manage the feedstock variability to inform harvest and storage best management practices.

ACS Sustainable Chemistry & Engineering published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Safety of 3-Hydroxydihydrofuran-2(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Lin, Yu-Len published the artcileCharacterization of bio-oils from fast pyrolysis of thorny bamboo (Bambusa stenostachya) and long-branch bamboo (B. dolichoclada), Category: tetrahydrofurans, the publication is Taiwan Linye Kexue (2013), 28(4), 203-216, database is CAplus.

In this study, thorny bamboo (Bambusa stenostachya) and long-branch (B. dolichoclada) bamboo were integrated as feedstock to produce pyrolysis liquid (bio-oil) using fast pyrolysis technol., and the basic properties of the bio-oils were analyzed. Results showed that the higher heating value (HHV) of both bio-oils were 13.92 MJ/kg for thorny bamboo and 14.87 MJ/kg for long-branch bamboo, and both HHVs were relatively low for use as bioenergy. The bio-oils need to be reprocessed using upgrading technologies to promote the efficiency of energy utilization. However, both bio-oils were analyzed by gas chromatog. mass spectrometry (GC-MS) and were shown to contain more than 80 different organic compounds with multifunctional groups. The major compounds in the bio-oil of long-branch bamboo were phenols with the largest proportion of >50%, and those of thorny bamboo included good distributions of phenols, carboxylic acids, and ketones. Both bio-oils are great potential resources beyond just a fossil fuel to provide various chem. compounds

Taiwan Linye Kexue published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Category: tetrahydrofurans.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Pearson, David published the artcileLC-MS based quantification of 2′-ribosylated nucleosides Ar(p) and Gr(p) in tRNA, HPLC of Formula: 87865-78-9, the publication is Chemical Communications (Cambridge, United Kingdom) (2011), 47(18), 5196-5198, database is CAplus and MEDLINE.

RNA nucleosides are often naturally modified into complex noncanonical structures with key biol. functions. Here the authors report LC-MS quantification of the Ar(p) and Gr(p) 2′-ribosylated nucleosides in tRNA using deuterium labeled standards, and the first detection of Gr(p) in complex fungi.

Chemical Communications (Cambridge, United Kingdom) published new progress about 87865-78-9. 87865-78-9 belongs to tetrahydrofurans, auxiliary class Nucleosides and Nucleotides,Nucleoside Analogues, name is N-(9-((6aR,8R,9R,9aS)-9-Hydroxy-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide, and the molecular formula is C26H45N5O7Si2, HPLC of Formula: 87865-78-9.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Alvarez, Alejandro published the artcileAroma compounds produced by liquid fermentation with Saccharomyces cerevisiae and Zygosaccharomyces rouxii from castor oil through cell permeabilization, Safety of 3-Hydroxydihydrofuran-2(3H)-one, the publication is Biocatalysis and Agricultural Biotechnology (2022), 102243, database is CAplus.

The use of microorganisms to produce aroma mols. is growing in the flavor and fragrance industries due to the increased market for natural products. In this study, the effect of the type of microorganism, and cellular permeabilization on the production of aroma mols. from castor oil by liquid fermentation with yeasts, was assessed for possible application in the production of natural flavors. Different treatments were assessed with a three-way factorial design (type of microorganism, cell permeabilization and amount of castor oil), the aroma profile was analyzed using gas chromatog. with mass spectrometry (GC-MS), and the treatments were classified by principal component anal. (PCA). The results showed a significant effect of the yeast S. cerevisiae and Z. rouxii, the permeabilization treatment, and the amount of castor oil in the production of aroma compounds (p < 0.05). The mols. 4-hydroxy-2-pentenoic acid γ-lactone, Me pyruvate, 2,3,4-trimethyl-3-pentanol, and δ-decalactone were affected by all the factors. The production of metabolites increased with the permeabilization treatments for certain mols. like ethanol and organic acids, whereas the generation of others decreased. The use of these microorganisms and cell permeabilization are promising approaches for producing mols. with applications in natural flavors.

Biocatalysis and Agricultural Biotechnology published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Safety of 3-Hydroxydihydrofuran-2(3H)-one.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Vats, Sharad published the artcileEvaluation of bioactive compounds and antioxidant potential of hydroethanolic extract of Moringa oleifera Lam. from Rajasthan, India, Application In Synthesis of 19444-84-9, the publication is Physiology and Molecular Biology of Plants (2017), 23(1), 239-248, database is CAplus and MEDLINE.

Moringa oleifera Lam., the miracle tree, is widely used as a traditional medicine. The analyses of phytochems. and antioxidant potential of hydroethanolic extract of various plant parts of M. oleifera revealed that leaves possessed the highest content of total phenolics (9.58 mg/g), β-carotene (14.10 mg/g) and lycopene (2.60 mg/g). Flowers and bark showed the highest content of total flavonoids (3.5 mg/g) and anthocyanin (52.80 mg/g), resp. Leaves also showed maximum antioxidant potential using nitric oxide scavenging assay (IC₅₀ – 120 μg/mL) and deoxyribose degradation assay (IC₅₀-178 μg/mL). Highest DPPH radical scavenging activity was observed in flowers (IC₅₀-405 μg/mL). The GC-MS study revealed the presence of 29, 36 and 24 compounds in bark, leaf and flower, resp. The major constituent identified were epiglobulol (41.68% in bark), phytol (23.54% in leaf) and β-sitosterol (15.35% in flower). The phytochems. identified possess several therapeutic activity, including antioxidant potential, which was confirmed through earlier reports. Moreover, the presence of 1,1,3-triethoxubutane in all the plant parts analyzed, projects it as an important source of waste water treatment as hydrophobic modifiers.

Physiology and Molecular Biology of Plants published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C6H11BF3KO, Application In Synthesis of 19444-84-9.

Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem