Humbert-Voss, Emelyne published the artcileSynthesis and conformational behavior of pseudopeptides containing δ-azaproline. A cis conformational preference for Xaa1-δ-azaPro bond, Synthetic Route of 19444-84-9, the publication is Tetrahedron (2014), 70(2), 363-370, database is CAplus.
δ-Azaproline, a new bis-nitrogen proline surrogate has been used in order to control the conformation of an AA-ΨPro bond. Conformational anal. of Xaa1-δ-azaPro-Xaa3 performed by NMR, IR experiments, and mol. modeling revealed a preference for a trans conformation of the Xaa1-δ-azaPro bond when δ-azaPro is protected by a Boc group. The removal of the Boc (Boc = tert-butoxycarbonyl) protection leads to the establishment of a C10 pseudocycle via a hydrogen bond network favoring the cis conformation of the Xaa1-δ-azaPro bond.
Tetrahedron published new progress about 19444-84-9. 19444-84-9 belongs to tetrahydrofurans, auxiliary class Tetrahydrofuran,Ester,Alcohol, name is 3-Hydroxydihydrofuran-2(3H)-one, and the molecular formula is C4H6O3, Synthetic Route of 19444-84-9.
Referemce:
https://en.wikipedia.org/wiki/Tetrahydrofuran,
Tetrahydrofuran | (CH2)3CH2O – PubChem