Lin28/let-7 crystal structures, purification protocols, and modified tumor suppressor hairpin oligonucleotides, suitable for use in Lin28 inhibitor screening assays and cancer therapy was written by Sliz, Piotr; Nam, Yunsun. And the patent was published on May 16,2013.Related Products of 550-33-4 The following contents are mentioned in the patent:
The invention provides oligonucleotides, compositions and methods for regulating let-7 microRNA biogenesis by inhibiting Lin28. The invention also relates to compositions and methods for screening inhibitors of Lin28 activity that increase the level of mature let-7 miRNA in a cell. The invention also relates to a method of treating or preventing cancer in a subject, using oligonucleotides to promote cellular processing of tumor suppressor miRNA in combination with other therapies. This study involved multiple reactions and reactants, such as (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4Related Products of 550-33-4).
(2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(9H-purin-9-yl)tetrahydrofuran-3,4-diol (cas: 550-33-4) belongs to tetrahydrofuran derivatives. THF (Tetrahydrofuran) is a stable compound with relatively low boiling point and excellent solvency. THF can also be synthesized by catalytic hydrogenation of furan. This allows certain sugars to be converted to THF via acid-catalyzed digestion to furfural and decarbonylation to furan, although this method is not widely practiced. THF is thus derivable from renewable resources.Related Products of 550-33-4
Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem