Month: October 2022

In 2022,Li, Guangchen; Xing, Yangyang; Zhao, Hui; Zhang, Jin; Hong, Xin; Szostak, Michal published an article in Angewandte Chemie, International Edition. The title of the article was 《Chemoselective Transamidation of Thioamides by Transition-Metal-Free N-C(S) Transacylation》.Name: 2,5-Dimethoxytetrahydrofuran The author mentioned the following in the article:

The first general, mild and highly chemoselective method for transamidation of thio-amides by NC(S) transacylation using non-nucleophilic anilines was reported. The method was broadly compatible with N-Ar tertiary thioamides and N-thioacyl-azoles as selective N-thioacyl transfer reagents. DFT studies that provided insight into the chemoselectivity of this new transamidation method and provided guidelines for the development of future transamidation methods of the thioamide bond.2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Name: 2,5-Dimethoxytetrahydrofuran) was used in this study.

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.Name: 2,5-Dimethoxytetrahydrofuran

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Reference of 2,5-DimethoxytetrahydrofuranIn 2020 ,《Towards the template synthesis of conjugated pyrrole based oligo-heteroaryls》 was published in Journal of the Indian Chemical Society. The article was written by Panda, Biswajit. The article contains the following contents:

Synthesis of polymers and Oligomers with various interesting phys. properties is a rewarding task for the chemist. oligoheteroaryls are a significant class of organic compounds due to their wide applicability in various fields. Here, in this article, the synthetic studies directed for the preparation of conjugated pyrrole based oligo-heteroaryls was reported. The successful synthesis of double stranded polymeric ladderphane using ring opening metathesis polymerizations (ROMP) and palladium catalyzed Suzuki coupling were the key feature of this work. Hydrolysis of the double stranded polymer was unsuccessful due to its insoluble nature. The effort to increase the solubility of the double stranded polymers by the incorporation of long-chain aliphatic counterpart is underway in our laboratory In the part of experimental materials, we found many familiar compounds, such as 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Reference of 2,5-Dimethoxytetrahydrofuran)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Reference of 2,5-Dimethoxytetrahydrofuran

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Computed Properties of C4H6O3On June 1, 2022, Wurzler, Gleicielle Tozzi; da Silva, Victor Teixeira; de Almeida Azevedo, Debora; Ana da Silva, Ayla Sant’; Noronha, Fabio Bellot published an article in Fuel Processing Technology. The article was 《Integrating bio-oil and carbohydrate valorization on the fractionation of sugarcane bagasse via Organosolv process using Mo2C-based catalysts》. The article mentions the following:

This work studied the fractionation of sugarcane bagasse via Organosolv treatment using isopropanol/water in the presence of Raney-Ni and molybdenum carbide catalysts (Bulk Mo2C and Mo2C supported on activated carbon (AC) or Al2O3). The degree of delignification, the bio-oil and solid residue composition depended on the type of catalyst. A partial extraction of hemicellulose occurred followed by depolymerization, resulting in a product distribution that depended on the catalyst. Raney-Ni catalyst promoted the formation of diols and triols, while xylose, furfural, and furan were mainly produced by Mo2C based-catalysts. The Organosolv treatment without catalyst and in the presence of bulk Mo2C produced a bio-oil containing mainly 2,3-dihydrobenzofuran. Mo2C/AC and Mo2C/Al2O3 are promising catalysts for the fractionation of sugarcane bagasse that produced a bio-oil with higher yield to substituted methoxyphenols and a solid residue more easily hydrolyzed by cellulases, producing higher yield to glucose than Raney-Ni catalyst. In the experiment, the researchers used 3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9Computed Properties of C4H6O3)

3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9) may be employed as starting reagent in the synthesis of series of seco-pseudonucleoside synthons via aminolysis. It may be employed as starting reagent in the synthesis of enantiomerically pure orthogonally protected δ-azaproline, via Mitsunobu reaction.Computed Properties of C4H6O3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

《Formal enantioselective total synthesis of bisdehydroneostemoninine》 was published in Journal of Asian Natural Products Research in 2020. These research results belong to Ma, Kai-Qing; Ren, Hu-Bin; Chao, Jian-Bin; Qin, Xue-Mei. Quality Control of 2,5-Dimethoxytetrahydrofuran The article mentions the following:

A formal enantioselective total synthesis of bisdehydroneostemoninine I employing L-glutamic acid as the chiral pool is described. The key features of the synthesis include regioselective and enantioselective opening of the chiral epoxide, (2R)-2-[3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]propyl]oxirane with dimethylsulfonium methylide and tandem Friedel-Crafts cyclization followed by lactonization to form a 5-7-5 tricyclic core of the target stemona alkaloids I. The synthetic route provides opportunities to explore the biol. behavior of enantiopure compound I.2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Quality Control of 2,5-Dimethoxytetrahydrofuran) was used in this study.

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.Quality Control of 2,5-Dimethoxytetrahydrofuran

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

In 2022,EL-Mahdy, Ahmed F. M.; Bakhite, Etify A.; Abdel-Hafez, Shams H.; Ibrahim, Omaima F.; Abdu-Allah, Hajjaj H. M.; Marae, Islam S. published an article in Journal of Heterocyclic Chemistry. The title of the article was 《Synthesis, characterization, and photophysical properties of some new thieno[2,3-b]pyridines bearing phenylethenyl moiety》.Reference of 2,5-Dimethoxytetrahydrofuran The author mentioned the following in the article:

The 5-acetyl-3-cyano-6-methyl-4-(2-phenylethenyl)pyridine-2(1H)-thione was synthesized by interaction of cinnamylidene-2-cyanothioacetamide and acetylacetone or via one-pot reaction of E-cinnamaldehyde, 2-cyanothioacetamide, and acetylacetone. Reaction of 5-acetyl-3-cyano-6-methyl-4-(2-phenylethenyl)pyridine-2(1H)-thione with Et iodide or N-chloroacetyl derivative of aromatic amines RC6H4NHC(O)CH2Cl (R = Me, OMe, acetyl, Cl) in boiling ethanol containing sodium ethoxide gave the 5-acetyl-3-cyano-2-ethylsulfanyl-6-methyl-4-(2-phenylethenyl)pyridine and 5-acetyl-3-amino-2-(N-arylcarbamoyl)-6-methyl-4-(2-phenylethenyl)thieno[2,3-b]pyridines I, resp. Compound I (R = Cl) was reacted with 2,5-dimethoxytetrahydrofuran or tri-Et orthoformate to furnish 5-acetyl-2-[N-(4-chlorophenyl)carbamoyl]-6-methyl-4-(2-phenylethenyl)-3-(1H-pyrrol-1-yl)- thieno[2,3-b]pyridine or 8-acetyl-3-(4-chlorophenyl)-7-methyl-9-(2-phenylethenyl)pyrido [3′,2′:4,5]thieno[3,2-d]pyrimidine-4(3H)-one, resp. The photophys. properties of I (Me, OMe, Cl), and 8-acetyl-3-(4-chlorophenyl)-7-methyl-9-(2-phenylethenyl)pyrido [3′,2′:4,5]thieno[3,2-d]pyrimidine-4(3H)-one were fully studied and the obtained results included herein. The fluorescence data confirmed that compounds I (Me, OMe, Cl), and 8-acetyl-3-(4-chlorophenyl)-7-methyl-9-(2-phenylethenyl)pyrido [3′,2′:4,5]thieno[3,2-d]pyrimidine-4(3H)-one exhibit aggregation-induced emission behavior with high absolute quantum yields. In the experimental materials used by the author, we found 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Reference of 2,5-Dimethoxytetrahydrofuran)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.Reference of 2,5-Dimethoxytetrahydrofuran

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

《Discovery of Potent and Selective Inhibitors of Ataxia Telangiectasia Mutated and Rad3 Related (ATR) Protein Kinase as Potential Anticancer Agents》 was written by Charrier, Jean-Damien; Durrant, Steven J.; Golec, Julian M. C.; Kay, David P.; Knegtel, Ronald M. A.; MacCormick, Somhairle; Mortimore, Michael; O’Donnell, Michael E.; Pinder, Joanne L.; Reaper, Philip M.; Rutherford, Alistair P.; Wang, Paul S. H.; Young, Stephen C.; Pollard, John R.. Reference of (S)-3-Iodotetrahydrofuran And the article was included in Journal of Medicinal Chemistry on April 14 ,2011. The article conveys some information:

DNA-damaging agents are among the most frequently used anticancer drugs. However, they provide only modest benefit in most cancers. This may be attributed to a genome maintenance network, the DNA damage response (DDR), that recognizes and repairs damaged DNA. ATR is a major regulator of the DDR and an attractive anticancer target. Herein, we describe the discovery of a series of aminopyrazines with potent and selective ATR inhibition. Compound (I) inhibits ATR with a Ki of 6 nM, shows >600-fold selectivity over related kinases ATM or DNA-PK, and blocks ATR signaling in cells with an IC50 of 0.42 μM. Using I, here it is shown that ATR inhibition markedly enhances death induced by DNA-damaging agents in certain cancers but not normal cells. This differential response between cancer and normal cells highlights the great potential for ATR inhibition as a novel mechanism to dramatically increase the efficacy of many established drugs and ionizing radiation. In the experimental materials used by the author, we found (S)-3-Iodotetrahydrofuran(cas: 918439-76-6Reference of (S)-3-Iodotetrahydrofuran)

(S)-3-Iodotetrahydrofuran(cas: 918439-76-6) is one of organic iodides. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles.Reference of (S)-3-Iodotetrahydrofuran

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

HPLC of Formula: 19444-84-9On October 7, 2019 ,《Toward Renewable-Based, Food-Applicable Prebiotics from Biomass: A One-Step, Additive-Free, Microwave-Assisted Hydrothermal Process for the Production of High Purity Xylo-oligosaccharides from Beech Wood Hemicellulose》 was published in ACS Sustainable Chemistry & Engineering. The article was written by Remon, Javier; Li, Tianzong; Chuck, Christopher J.; Matharu, Avtar S.; Clark, James H.. The article contains the following contents:

Xylooligosaccharides (XOS) produced from biomass offer a plethora of excellent physicochem. and physiol. properties to be used as natural prebiotic nutraceuticals. Herein, this work first addresses and optimizes a novel one-pot, additive-free, microwave-assisted process to produce high purity XOS from beech wood hemicellulose, studying the influence of the temperature, reaction time, and solid loading. These variables exerted a significant influence, allowing the transformation of hemicellulose into a gas (0-19%), an XOS-rich liquid product (9-80%) and a spent solid material (17-90%). The liquid phase consisted of a mixture of XOS with a d.p. (DP) DP > 6 (75-100 C-weight %) and DP 3-6 (0-10 C-weight %), together with mono/disaccharides (0-1 C-weight %), carboxylic acids (0-5 C-weight %), ketones (0-12 C-weight %) and furans (0-12 C-weight %). A good compromise between the liquid yield (81%) and XOS purity (96 C-weight %) was achieved at 172 °C using a solid loading of 5 weight % for 47 min. This time could be reduced (33 min) and the solid loading increased (25 weight %) without substantially altering the XOS (98 C-weight %) purity, although the liquid yield was reduced. The liquid yield could be increased up to 97% at the expenses of XOS purity (90 C-weight %) at 177 °C using a 5 weight % solid loading for 60 min. For these optima, the microwave production costs shifted between 1.42 and 6.50 euro/kg XOS, which is substantially lower than the XOS market price, thus highlighting the high potential of this emerging technol. Novel microwave-assisted hydrothermal process assessed and optimized for the production of food-applicable prebiotic nutraceuticals from beech wood hemicellulose.3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9HPLC of Formula: 19444-84-9) was used in this study.

3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9) may be employed as starting reagent in the synthesis of series of seco-pseudonucleoside synthons via aminolysis. It may be employed as starting reagent in the synthesis of enantiomerically pure orthogonally protected δ-azaproline, via Mitsunobu reaction.HPLC of Formula: 19444-84-9

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

《Pseudo-5-Fold-Symmetrical Ligand Drives Geometric Frustration in Porous Metal-Organic and Hydrogen-Bonded Frameworks》 was written by Haase, Frederik; Craig, Gavin A.; Bonneau, Mickaele; Sugimoto, Kunihisa; Furukawa, Shuhei. Electric Literature of C6H12O3 And the article was included in Journal of the American Chemical Society in 2020. The article conveys some information:

Reticular framework materials thrive on designability, but unexpected reaction outcomes are crucial in exploring new structures and functionalities. By combining “”incompatible”” building blocks, we employed geometric frustration in reticular materials leading to emergent structural features. The combination of a pseudo-C5-sym. organic building unit based on a pyrrole core with a C4-sym. copper paddlewheel synthon led to three distinct frameworks by tuning the synthetic conditions. The frameworks show structural features typical for geometric frustration: self-limiting assembly, internally stressed equilibrium structures, and topol. defects in the equilibrium structure, which manifested in formation of a hydrogen-bonded framework, distorted and broken secondary building units, and dangling functional groups, resp. The influence of geometric frustration on the CO2 sorption behavior and the discovery of a new secondary building unit shows geometric frustration can serve as a strategy to obtain highly complex porous frameworks.2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Electric Literature of C6H12O3) was used in this study.

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.Electric Literature of C6H12O3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Electric Literature of C6H12O3In 2019 ,《Driving Recursive Dehydration by PIII/PV Catalysis: Annulation of Amines and Carboxylic Acids by Sequential C-N and C-C Bond Formation》 appeared in Journal of the American Chemical Society. The author of the article were Lecomte, Morgan; Lipshultz, Jeffrey M.; Kim-Lee, Shin-Ho; Li, Gen; Radosevich, Alexander T.. The article conveys some information:

Pyrrolylanilines such as I, pyrrolylbenzylamines, and arylethylamines underwent chemoselective tandem condensation and cyclocondensation reactions with carboxylic acids such as RCO2H mediated by di-Et bromomalonate or di-Et bromo(methyl)malonate and phenylsilane or diphenylsilane in the presence of a hexamethylphosphetane oxide to yield pyrroloquinoxaline such as II [R = MeOCH2, n-Pr, H2C:CHCH2CH2, Ph, 2-MeC6H4, 3-MeC6H4, 4-ClC6H4, 4-FC6H4, 4-MeOC6H4, PhCH2SCH2, TsNHCH2, Br(CH2)5, 3-chloro-1-cyclobutyl], pyrrolobenzodiazepines, a dihydro-β-carboline, and dihydroisoquinolines. The method was also used for Bischler-Napieralski cyclocondensations of aralkyl amides. A bromophosphonium bromide was generated as the key intermediate. A PIII/PV redox catalyst enabled iterative redox-neutral transformations complementary to reactions using the reductive driving force of the PIII/PV couple. In the experiment, the researchers used many compounds, for example, 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Electric Literature of C6H12O3)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Electric Literature of C6H12O3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

《Hydrothermal Extraction of Valuable Components from Leaves and Petioles from Paulownia elongata x fortunei》 was written by Rodriguez-Seoane, Paula; del Pozo, Cristina; Puy, Neus; Bartroli, Jordi; Dominguez, Herminia. SDS of cas: 19444-84-9 And the article was included in Waste and Biomass Valorization on August 31 ,2021. The article conveys some information:

Abstract: The leaves and petioles of Paulownia elongata x fortunei are residual fractions from the tree plantations com. destined to the production of wood and their valorization could contribute to the rational utilization of this resource. The saccharidic fraction is the most abundant in both parts of the plant and the sugar profile is very similar, but the ethanol extractives are more abundant in leaves. Non isothermal processing was selected since it provided better results than isothermal extraction with shorter times. For this reason, optimization of autohydrolysis under non isothermal operation (140-240°C) was performed for both materials: leaves and petioles. The final autohydrolysis temperature highly influenced the saccharidic, proteic, phenolic and volatile composition of the extracts Operating under selected conditions leaves provided extracts with more antioxidant compounds than petioles. The proposed technol. provides a variety of com. valuable components, which could contribute to the integral use of this energetic crop following a biorefinery approach. Graphic Abstract: [graphic not available: see fulltext]. In the part of experimental materials, we found many familiar compounds, such as 3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9SDS of cas: 19444-84-9)

3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9) may be employed as starting reagent in the synthesis of series of seco-pseudonucleoside synthons via aminolysis. It may be employed as starting reagent in the synthesis of enantiomerically pure orthogonally protected δ-azaproline, via Mitsunobu reaction.SDS of cas: 19444-84-9

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem