Month: October 2022

Li, Lei; Huang, Kai-Lieh; Gao, Yipeng; Cui, Ya; Wang, Gao; Elrod, Nathan D.; Li, Yumei; Chen, Yiling Elaine; Ji, Ping; Peng, Fanglue; Russell, William K.; Wagner, Eric J.; Li, Wei published the artcile< An atlas of alternative polyadenylation quantitative trait loci contributing to complex trait and disease heritability>, Recommanded Product: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate, the main research area is human alternative polyadenylation QTL linkage mapping disease heritability.

Genome-wide association studies have identified thousands of noncoding variants associated with human traits and diseases. However, the functional interpretation of these variants is a major challenge. Here, we constructed a multi-tissue atlas of human 3’UTR alternative polyadenylation (APA) quant. trait loci (3’aQTLs), containing approx. 0.4 million common genetic variants associated with the APA of target genes, identified in 46 tissues isolated from 467 individuals (Genotype-Tissue Expression Project). Mechanistically, 3’aQTLs can alter poly(A) motifs, RNA secondary structure and RNA-binding protein-binding sites, leading to thousands of APA changes. Our CRISPR-based experiments indicate that such 3’aQTLs can alter APA regulation. Furthermore, we demonstrate that mapping 3’aQTLs can identify APA regulators, such as La-related protein 4. Finally, 3’aQTLs are colocalized with approx. 16.1% of trait-associated variants and are largely distinct from other QTLs, such as expression QTLs. Together, our findings show that 3’aQTLs contribute substantially to the mol. mechanisms underlying human complex traits and diseases.

Nature Genetics published new progress about 3′-Untranslated region Role: BSU (Biological Study, Unclassified), PRP (Properties), BIOL (Biological Study). 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Recommanded Product: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Goryanova, Bogdana; Amyes, Tina L.; Richard, John P. published the artcile< Role of the Carboxylate in Enzyme-Catalyzed Decarboxylation of Orotidine 5'-Monophosphate: Transition State Stabilization Dominates Over Ground State Destabilization>, Product Details of C9H13N2O9P, the main research area is decarboxylation orotidine monophosphate decarboxylase transition state stabilization.

Kinetic parameters kex (s-1) and kex/Kd (M-1s-1) are reported for exchange for deuterium in D2O of the C-6 hydrogen of 5-fluororotidine 5′-monophosphate (FUMP) catalyzed by the Q215A, Y217F, and Q215A/Y217F variants of yeast orotidine 5′-monophosphate decarboxylase (ScOMPDC) at pD 8.1, and by the Q215A variant at pD 7.1-9.3. The pD rate profiles for wildtype ScOMPDC and the Q215A variant are identical, except for a 2.5 log unit downward displacement in the profile for the Q215A variant. The Q215A, Y217F and Q215A/Y217F substitutions cause 1.3-2.0 kcal/mol larger increases in the activation barrier for wildtype ScOMPDC-catalyzed deuterium exchange compared with decarboxylation, because of the stronger apparent side chain interaction with the transition state for the deuterium exchange reaction. The stabilization of the transition state for the OMPDC-catalyzed deuterium exchange reaction of FUMP is ca. 19 kcal/mol smaller than the transition state for decarboxylation of OMP, and ca. 8 kcal/mol smaller than for OMPDC-catalyzed deprotonation of FUMP to form the vinyl carbanion intermediate common to OMPDC-catalyzed reactions OMP/FOMP and UMP/FUMP. We propose that ScOMPDC shows similar stabilizing interactions with the common portions of decarboxylation and deprotonation transition states that lead to formation of this vinyl carbanion intermediate, and that there is a large ca. (19-8) = 11 kcal/mol stabilization of the former transition state from interactions with the nascent CO2 of product. The effects of Q215A and Y217F substitutions on kcat/Km for decarboxylation of OMP are expressed mainly as an increase in Km for the reactions catalyzed by the variant enzymes, while the effects on kex/Kd for deuterium exchange are expressed mainly as an increase in kex. This shows that the Q215 and Y217 side chains stabilize the Michaelis complex to OMP for the decarboxylation reaction, compared with the complex to FUMP for the deuterium exchange reaction. These results provide strong support for the conclusion that interactions which stabilize the transition state for ScOMPDC-catalyzed decarboxylation at a nonpolar enzyme active site dominate over interactions that destabilize the ground-state Michaelis complex.

Journal of the American Chemical Society published new progress about Enzyme functional sites, active. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Product Details of C9H13N2O9P.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Kato, Shunsuke; Yusof, Fitri Adila Amat; Harimoto, Toyohiro; Takada, Kenji; Kaneko, Tatsuo; Kawai, Mika; Mitsumata, Tetsu published the artcile< Electric volume resistivity for biopolyimide using 4,4'-diamino-α-truxillic acid and 1,2,3,4-cyclobutanetetracarboxylic dianhydride>, Safety of Cyclobuta[1,2-c:3,4-c’]difuran-1,3,4,6(3aH,3bH,6aH,6bH)-tetraone, the main research area is biopolyimide film volume resistivity elec insulation property; biopolyimide; biopolymer; electric resistivity; polyimide.

Biopolyimides poly(ATA-CBDA), made from of 4,4′-diamino-α-truxillic acid di-Me ester (ATA) and 1,2,3,4-cyclobutanetetracarboxylic dianhydride (CBDA), is synthesized and measured its elec. volume resistivity at various exptl. conditions. The effects of film size, thickness, drying time, and the elec. field strength on elec. resistivity are investigated and compared with polyimide (Kapton). The elec. resistivity for all polyimide and biopolyimide are distributed in the range of 1015-1016 Ωcm, which shows that biopolyimide has high elec. insulation as well as polyimide. The elec. resistivity strongly depends on film thickness, which suggests that elec. resistivity is a function of elec. field strength. The critical elec. field for polyimide and biopolyimide films are determined to be 5.8 x 107 V/m and 3.2 x 107 V/m, resp. Humidity was found to strongly affect the elec. resistivity; ~1016 Ωcm at 34% RH and ~1013 Ωcm at 60% RH for both polyimide and biopolyimide films.

Polymers (Basel, Switzerland) published new progress about Electric breakdown. 4415-87-6 belongs to class tetrahydrofurans, and the molecular formula is C8H4O6, Safety of Cyclobuta[1,2-c:3,4-c’]difuran-1,3,4,6(3aH,3bH,6aH,6bH)-tetraone.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Povedano, M; Martínez, Y; Tejado, A; Arroyo, P; Tebe, C; Lorenzo, J L; Montero, J published the artcile< Observational pilot study of patients with carpal tunnel syndrome treated with Nucleo CMP Forte™.>, Synthetic Route of 58-97-9, the main research area is carpal tunnel syndrome; electromyography; nucleotides; pain.

AIM: Carpal tunnel syndrome (CTS) is a very common entrapment neuropathy characterized by pain and paresthesia in the territory of the median nerve. Although this syndrome has a considerable impact on the patient’s quality of life, its medical treatment is far from optimal. MATERIAL & METHODS: We performed an observational study to evaluate Nucleo CMP ForteTM in patients with electromyography-confirmed, mild-moderate CTS. Pain was assessed using a visual analog scale, electromyogram and the SF-36. RESULTS: Pain decreased significantly after 6 months. Quality of life improved significantly in the pain dimensions. No significant differences were observed in electromyographic findings. No adverse events were reported. CONCLUSIONS: Nucleotides could prove useful for the nonsurgical treatment of CTS. Further studies are necessary to confirm this.

Pain management published new progress about 58-97-9. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Synthetic Route of 58-97-9.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Kumar, Abhinav; Srivastava, Rajendra published the artcile< Pd-Decorated Magnetic Spinels for Selective Catalytic Reduction of Furfural: Interplay of a Framework-Substituted Transition Metal and Solvent in Selective Reduction>, Related Products of 97-99-4, the main research area is selective reduction furfural palladium magnetic spinel.

The reduction of functional platform chems., such as furfural, to industrially important chems. and fuel requires precise modulation of surface reactivity of the catalyst to obtain the desired reactivity and selectivity. In this study, the selective reduction of furfural (FAL) to furfuryl alc. (FOL) and tetrahydrofurfuryl alc. (THFA) is achieved by the transition metal interplay in the framework structure of magnetic spinels Fe3O4 and by modulating the reaction medium. Herein, FAL is selectively and quant. reduced to FOL in water at very mild reaction conditions over Pd-decorated CuFe2O4, whereas FAL is selectively converted to THFA in hexane at mild reaction conditions over Pd-decorated NiFe2O4, using H2 as an economical reducing agent. The Pd loading, reaction temperature, H2 pressure, and reaction time are minimized to obtain the best selectivity toward THFA. Different modes of FAL adsorption occur on CuFe2O4 and NiFe2O4 surfaces. Dissociative adsorption of H2 occurs on Pd sites to form Pd-H species, followed by transfer hydrogenation from Pd-H to FAL adsorbed on spinels, leading to the formation of FOL or THFA. Efficient magnetic recyclability and the hot filtration test show that the catalyst exhibits no significant loss in the activity even after five recycles. Catalysts exhibit very high activity, selectivity, and low activation energy, which are very attractive for academic and industrial points of view.

ACS Applied Energy Materials published new progress about Activation energy. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Related Products of 97-99-4.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Liu, Qiaoyun; Qiao, Botao; Liu, Fei; Zhang, Leilei; Su, Yang; Wang, Aiqin; Zhang, Tao published the artcile< Catalytic production of 1,4-pentanediol from furfural in a fixed-bed system under mild conditions>, Category: tetrahydrofurans, the main research area is catalytic pentanediol furfural fixed bed system.

Furfural is one of the most important biomass-derived chems. Its large-scale availability calls for the exploration of new transformation methods for further valorization. Here we report on the direct, one-step conversion of furfural into 1,4-pentanediols (1,4-PeDs) using a combination of Amberlyst-15 and Ru-FeOx/AC catalysts. It is interesting to find that the introduction of a suitable amount of FeOx results in a great improvement in the dispersion of Ru and a decrease in the Lewis acidity. Both XPS and H2-TPR show that there is electron transfer from Ru to Fe, and the electronic interaction facilitates the reduction of both Ru and Fe species. When used in combination with Amberlyst-15, the Ru-6.3FeOx/AC catalyst afforded the best performance with a 1,4-PeD yield of 86%; by contrast, Ru/AC free of FeOx only gave levulinic acid as the major product, demonstrating the key role of the acid/metal balance in the one-pot conversion of furfural to 1,4-PeD. Moreover, such a dual catalyst exhibited excellent durability within 175 h time-onstream.

Green Chemistry published new progress about Biomass. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Category: tetrahydrofurans.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Cao, Peng; Lin, Lu; Qi, Haifeng; Chen, Rui; Wu, Zhijie; Li, Ning; Zhang, Tao; Luo, Wenhao published the artcile< Zeolite-Encapsulated Cu Nanoparticles for the Selective Hydrogenation of Furfural to Furfuryl Alcohol>, Electric Literature of 97-99-4, the main research area is zeolite encapsulated copper nanoparticle hydrogenation furfural furfuryl alc.

Catalytic hydrogenation of furfural (FFL) to furfuryl alc. (FAL) is one of the pivotal reactions for biomass valorization. Herein, well-defined Cu nanoparticles of ~1.8 nm encapsulated within titanium silicalite-1 (TS-1) have been successfully prepared by an in situ encapsulation approach, which possesses significant advantages in metal dispersion and uniformity compared to the traditional wet impregnation method. After a Na ion-exchange process for modulation of the zeolite microenvironment, the obtained Na-Cu@TS-1 catalyst affords an enhanced activity and selectivity in the selective hydrogenation of FFL into FAL, with a FFL conversion of 93.0% and a FAL selectivity of 98.1% at 110°C, 10 bar H2, after a reaction time of 2 h. A turnover frequency value of 55.2 h-1 has been achieved, reflecting some of the highest activity for Cu-based heterogeneous catalysts under similar conditions. Comprehensive characterization studies reveal that the confined environment of the zeolite could not only provide the spatial restriction for metal particles but also induce an electronic interaction between encapsulated Cu nanoparticles and Ti species in Na-Cu@TS-1, which both lead to effective suppression of the metal aggregation and leaching during catalysis. Na species, added by the ion exchange, not only mediate the acid/basic property of the zeolite for suppressing the side reactions but also modulate the encapsulated Cu species into an electronic-rich state, facilitating the FFL hydrogenation. Deactivation of Na-Cu@TS-1 is primarily caused by Na leaching into the liquid phase, but activity can be almost restored after a Na readdn. process.

ACS Catalysis published new progress about Adsorption. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Electric Literature of 97-99-4.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Latini, Alessandra; Orsini, Diego; Ambrifi, Marina; Colafigli, Manuela; Zaccarelli, Mauro; Cristaudo, Antonio published the artcile< Classical Kaposi's sarcoma concurrent with ledipasvir-sofosbuvir therapy for hepatitis C infection.>, Electric Literature of 58-97-9, the main research area is .

There is no abstract available for this document.

Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia published new progress about 58-97-9. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Electric Literature of 58-97-9.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Wang, Chunhua; Wang, Anjie; Yu, Zhiquan; Wang, Yao; Sun, Zhichao; Kogan, Victor M.; Liu, Ying-Ya published the artcile< Aqueous phase hydrogenation of furfural to tetrahydrofurfuryl alcohol over Pd/UiO-66>, Quality Control of 97-99-4, the main research area is hydrogenation furfural tetrahydrofurfuryl palladium catalyst.

A Pd/UiO-66 catalyst was synthesized with well-dispersed Pd nanoparticles. The obtained catalyst was tested in the hydrogenation of furfural to tetrahydrofurfuryl alc. in various solvents, Water was the most suitable solvent. Pd/UiO-66 exhibited much higher activity than Pd/SiO2 and Pd/γ-Al2O3, completely converting furfural to tetrahydrofurfuryl alc. with 100% selectivity under mild conditions. The hydrogenation of C=O moiety in tetrahydrofurfural was rate-determining step. Static adsorption measurement indicated that the adsorption of furfural on UiO-66 was significantly stronger than that on SiO2 or γ-Al2O3, suggesting that the adsorption play an important role in the gas-liquid-solid furfural hydrogenation reaction.

Catalysis Communications published new progress about Catalyst supports. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Quality Control of 97-99-4.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Gao, Guoming; Shao, Yuewen; Gao, Yong; Wei, Tao; Gao, Guanggang; Zhang, Shu; Wang, Yi; Chen, Qifeng; Hu, Xun published the artcile< Synergetic effects of hydrogenation and acidic sites in phosphorus-modified nickel catalysts for the selective conversion of furfural to cyclopentanone>, Recommanded Product: (Tetrahydrofuran-2-yl)methanol, the main research area is synergetic hydrogenation acidic phosphorus nickel catalyst furfural cyclopentanone.

Cyclopentanone (CPO) is a value-added chem. that can be produced from furfural via hydrogenation coupled with an acid-catalysis step. Developing an effective bi-functional catalyst remains a challenge to be overcome. In this study, phosphorus was introduced to Ni/Al2O3 to modify the distribution of acidic sites and to tailor the activity of the metal sites for hydrogenation, with the aim of developing an active and cost-effective transition-metal-based catalyst for the conversion of furfural to CPO. The results showed that phosphorus species could react with both alumina and metallic nickel, forming an AlPO4 phase and nickel phosphide species. The formation of the AlPO4 phase reduced the specific area of the catalyst and increased the abundance of acidic sites. The formation of nickel phosphide species (Ni2P, Ni3P, and Ni12P5) tailored the selectivity of the hydrogenation sites. Furfural was only hydrogenated to furfuryl alc. (FA), while further hydrogenation to tetrahydrofurfuryl alc. (TFA) was inhibited. The introduced acidic sites further catalyzed the conversion of the formed FA to CPO. The balanced distribution of the hydrogenation sites and the acidic sites, as well as their tailored activity for hydrogenation and acid-catalyzed reactions, was crucial for the selective conversion of furfural to CPO.

Catalysis Science & Technology published new progress about Acid catalysis. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Recommanded Product: (Tetrahydrofuran-2-yl)methanol.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem