SDS of cas: 696-59-3In 2020 ,《Pyrrolo[1,2-a]quinoxalines: Insulin Mimetics that Exhibit Potent and Selective Inhibition against Protein Tyrosine Phosphatase 1B》 appeared in ChemMedChem. The author of the article were Garcia-Marin, Javier; Griera, Mercedes; Sanchez-Alonso, Patricia; Di Geronimo, Bruno; Mendicuti, Francisco; Rodriguez-Puyol, Manuel; Alajarin, Ramon; de Pascual-Teresa, Beatriz; Vaquero, Juan J.; Rodriguez-Puyol, Diego. The article conveys some information:
PTP1B dephosphorylates insulin receptor and substrates to modulate glucose metabolism This enzyme is a validated therapeutic target for type 2 diabetes, but no current drug candidates have completed clin. trials. Pyrrolo[1,2-a]quinoxalines substituted at positions C1-C4 and/or C7-C8 were found to be nontoxic to cells and good inhibitors in the low- to sub-micromolar range, with the 4-benzyl derivative being the most potent inhibitor (0.24 μm). Some analogs bearing chlorine atoms at C7 and/or C8 kept potency and showed good selectivity compared to TCPTP (selectivity index >40). The most potent inhibitors behaved as insulin mimetics by increasing glucose uptake. The 4-benzyl derivative inhibited insulin receptor substrate 1 and AKT phosphorylation. Mol. docking and mol. dynamics simulations supported a putative binding mode for these compounds to the allosteric α3/α6/α7 pocket, but inconsistent results in enzyme inhibition kinetics were obtained due to the high tendency of these inhibitors to form stable aggregates. Computational calculations supported the druggability of inhibitors. In the experiment, the researchers used many compounds, for example, 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3SDS of cas: 696-59-3)
2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.SDS of cas: 696-59-3
Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem