Chemistry involves the study of all things chemical – chemical processes, chemical compositions and chemical manipulation – in order to better understand the way in which materials are structured, how they change and how they react in certain situations. COA of Formula: C21H21F2N3O4S
The invention discloses a method for preparation of posaconazole, first of all, BP004b04 with oxalic acid to form the salt, to obtain the POE; secondly, POE with di-tert-butyl b carbon ester in the presence of an alkali reaction to obtain POP, POP recrystallization; once again, with the POK POP in the presence of an alkali reaction to obtain the POR, POR removes uncle butyl carbonate protecting group, to obtain POS; finally POS POB ring obtained, with the POB POA reaction posaconazole. The method of the invention, obtained in the posaconazole, the diastereoisomeric isomer content ? 0.01%, and the whole route total yield is high. (by machine translation)
A catalyst does not appear in the overall stoichiometry of the reaction it catalyzes. In my other articles, you can also check out more blogs about 149809-43-8. COA of Formula: C21H21F2N3O4S
Reference：
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem