One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Quality Control of Tetrahydrofuran-3-carboxylic acid, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 89364-31-8, Name is Tetrahydrofuran-3-carboxylic acid, molecular formula is C5H8O3
Tau prions feature in the brains of patients suffering from Alzheimer’s disease and other tauopathies. For the development of therapeutics that target the replication of tau prions, a high-content, fluorescence-based cell assay was developed. Using this high-content phenotypic screen for nascent tau prion formation, a 4-piperazine isoquinoline compound (1) was identified as a hit with an EC50 value of 390 nM and 0.04 Kp,uu. Analogs were synthesized using a hypothesis-based approach to improve potency and in vivo brain penetration resulting in compound 25 (EC50 = 15 nM; Kp,uu = 0.63). We investigated the mechanism of action of this series and found that a small set of active compounds were also CDK8 inhibitors.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Quality Control of Tetrahydrofuran-3-carboxylic acid, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 89364-31-8, in my other articles.
Reference：
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem