Application of 111769-27-8, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 111769-27-8, molcular formula is C11H17NO4S, introducing its new discovery.
Condensation of Nalpha-tosylated amino acid and peptide esters with alcohols (MeOH, EtOH, iPrOH) in the presence of the triphenylphosphine-diethyl azodicarboxylate adduct produced excellent yields of the corresponding Nalpha-alkylated derivatives. Optically pure Nalpha-alkylamino acids can only be obtained from methyl and benzyl esters using iodotrimethylsilane and hydrogenolysis, respectively, for the carboxy-deprotection and sodium in liquid ammonia for the amino-deprotection. That carboxy-deprotection of methyl esters by saponification is accompanied by racemization was established by high-performance liquid chromatography studies. Alkylation rates and yields for the reactions examined were found to depend only on the relative positions of the tosylamino and the carboxy functions. Removal of the carboxy group from the alpha-position resulted in longer reaction times and significant decreases in the yield of the desired N-alkylated derivatives. Accordingly, tosyl-protected lysyl and ornithyl side-chains of fully protected amino acids and peptides were selectively N-methylated in moderate yields in the presence of other amino functions bearing the tert-butoxycarbonyl (Boc) group which is commonly used for protection in peptide synthesis.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 111769-27-8 is helpful to your research. Application of 111769-27-8
Reference：
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem