Application of 21461-84-7, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.21461-84-7, Name is (S)-( )-5-Oxo-2-tetrahydrofurancarboxylic Acid, molecular formula is C5H6O4. In a Article，once mentioned of 21461-84-7
Indirubins have been identified as potent ATP-competitive protein kinase inhibitors. Structural modifications in the 5-and 3?-position have been extensively investigated, but the impact of substituents in 5?-position is not equally well-studied. Here, we report the synthesis of new indirubin 3?-and 5?-derivatives in the search of water-soluble indirubins by introducing basic centers. Antiproliferative activity of all compounds in tumor cells was evaluated along with kinase inhibition of selected compounds. The results show the 3?-position to tolerate large substituents without compromising activity, whereas bulk and rigid substituents in 5?-position appear unfavorable. Screening molecular targets of water-soluble 3?-oxime ethers revealed 6ha as preferential inhibitor of insulin-like growth factor 1 receptor (IGF-1R) in a panel of 22 protein kinases and in cells. Consistently, 6ha inhibited tumor cell growth in the NCI 60 cell line panel and induced apoptosis. The results indicate that the 5?-position provides limited space for chemical modifications and identify 6ha as a potent water-soluble indirubin-based IGF-1R inhibitor.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 21461-84-7
Reference：
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem