Related Products of 149809-43-8, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.149809-43-8, Name is ((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methyl 4-methylbenzenesulfonate, molecular formula is C21H21F2N3O4S. In a Patent£¬once mentioned of 149809-43-8
The invention belongs to the field of medical technology, relates to a method of preparing intermediates of posaconazole, and the intermediate for the preparation of a new method of posaconazole. The method comprises the following steps: a) of formula III compound of the formula IV compound under alkaline condition, for […] etherification reaction in a solvent to obtain the compound of formula V; b) type V compounds of palladium and formic acid under the conditions of the reaction intermediate type II compounds posaconazole; c) of formula II compound alkali hydrolysis reaction to obtain the posaconazole. The method of the invention compared with the known method of the invention, the invention is a process for preparing posaconazole intermediate II of the new method, and the intermediate II alkali hydrolysis to obtain the final product posaconazole I; compared with the prior process, the new process of the present invention purified difficulty is greatly reduced, greatly reduces the impurity of the product, significantly improving the purity, reduces the amount of heavy crystallization times, improves the yield, and reduces the production cost, the operation is simple, safe and reliable, is extremely suitable for industrial production. (by machine translation)
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 149809-43-8
Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem