Because a catalyst decreases the height of the energy barrier, 89364-31-8, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.89364-31-8, Name is Tetrahydrofuran-3-carboxylic acid, molecular formula is C5H8O3. In a article£¬once mentioned of 89364-31-8
Ketones from Nickel-Catalyzed Decarboxylative, Non-Symmetric Cross-Electrophile Coupling of Carboxylic Acid Esters
Synthesis of the C?C bonds of ketones relies upon one high-availability reagent (carboxylic acids) and one low-availability reagent (organometallic reagents or alkyl iodides). We demonstrate here a ketone synthesis that couples two different carboxylic acid esters, N-hydroxyphthalimide esters and S-2-pyridyl thioesters, to form aryl alkyl and dialkyl ketones in high yields. The keys to this approach are the use of a nickel catalyst with an electron-poor bipyridine or terpyridine ligand, a THF/DMA mixed solvent system, and ZnCl2 to enhance the reactivity of the NHP ester. The resulting reaction can be used to form ketones that have previously been difficult to access, such as hindered tertiary/tertiary ketones with strained rings and ketones with alpha-heteroatoms. The conditions can be employed in the coupling of complex fragments, including a 20-mer peptide fragment analog of Exendin(9?39) on solid support.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. 89364-31-8, In my other articles, you can also check out more blogs about 89364-31-8
Reference£º
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem