19311-37-6, 3-Bromotetrahydrofuran is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A solution of 3-[4-(4-methylpiperazin-1-yl)phenyl]-1-{[2-(trimethylsilyl)ethoxy]methyl}-1,5-dihydro-6H-pyrazolo[4,3-c]pyridin-6-one (15.0 mg, 0.034 mmol, Example 1, Step 3), iodocyclohexane (7.2 mg, 0.034 mmol) and cesium carbonate (33.4 mg, 0.102 mmol) in N,N-dimethylformamide (2.0 mL) was stirred at 80 C. for 18 h. After cooling to room temperature, the mixture was concentrated in vacuo. The crude mixture was then dissolved in DCM (2.0 mL) and TFA (2.0 mL) was added dropwise at room temperature. After stirring for 2 h, the mixture was concentrated in vacuo. The crude mixture was dissolved in MeOH (3.5 mL) and 10% aqueous NH4OH (1.5 mL) was added. The mixture was purified with prep-LCMS (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% TFA, at flow rate of 60 mL/min) to give the desired product. LCMS calculated for C23H30N5O (M+H)+: m/z=392.2; Found: 392.3. This compound was prepared according to the procedures described in Example 9, using 3-bromotetrahydrofuran instead of iodocyclohexane as starting material. LCMS calculated for C21H26N5O2 (M+H)+: m/z=380.2; Found: 380.3., 19311-37-6
19311-37-6 3-Bromotetrahydrofuran 12929516, aTetrahydrofurans compound, is more and more widely used in various fields.
Reference£º
Patent; Incyte Corporation; Ye, Qinda; Liu, Kai; Pan, Jun; Sokolsky, Alexander; Vechorkin, Oleg; Yao, Wenqing; (40 pag.)US2018/72719; (2018); A1;,
Tetrahydrofuran – Wikipedia
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