With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19311-37-6,3-Bromotetrahydrofuran,as a common compound, the synthetic route is as follows.
To the saturated Na2S03 aqueous solution (20.0 mL) was added 3-bromotetrahydrofuran (2.00 g, 14.83 mmol). The mixture was heated to reflux and stirred for 24hand then concentrated in vacuo. The residue was stirred with EtOH (30 mL) at 50 oc for 30min, then filtered immediately. The filtrate was concentrated in vacuo and the residue was driedin vacuo to give the title compound as a white solid (1.81 g, yield 72.6%).MS (ESI, neg. ion) m/z: 151.1 [M-Nar;1H NMR (400 MHz, DMSO-d6) 8 (ppm): 3.80 (t, J = 8.6 Hz, 1H), 3.71-3.64 (m, 2H), 3.63-3.57(m, 1H), 3.20-3.11 (m, 1H), 2.02-1.87 (m, 2H).
19311-37-6, The synthetic route of 19311-37-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; SUNSHINE LAKE PHARMA CO., LTD.; CALITOR SCIENCES, LLC; DAI, Weilong; XI, Ning; LI, Minxiong; ZHANG, Tao; LI, Xiaobo; HU, Haiyang; CHEN, Wuhong; WANG, Tingjin; LIU, Jun; (188 pag.)WO2017/48675; (2017); A1;,
Tetrahydrofuran – Wikipedia
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