With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.124391-75-9,(S)-(Tetrahydrofuran-3-yl)methanol,as a common compound, the synthetic route is as follows.
A mixture comprising 10.0 g of (tetrahydro-3-furanyl) methanol, 29.5 g of trifluoromethanesulfonic anhydride, 10.0 g of pyridine and 200 ml of dichloromethane was stirred for an hour at room temperature. Water was poured into the reaction solution to separate the organic layer, which was washed with 1 N hydrochloric acid, water and a saturated saline solution, dried, and concentrated to obtain 20 g [OF 3-TETRAHYDRO-FURANYLMETHYL TRIFLATE.] 3.25 g of 60% sodium hydride were added to 12.5 g of [1,] [5-DIMETHYL-2-NITROIMINOHEXAHYDRO-1,] 3,5-triazine and 60 ml of DMF at room temperature, followed by stirring for an hour. 20.0 g of the 3- [TETRAHYDROFURANYLMETHYL] [TRIFLATE] were added thereto, and the mixture was stirred at [50] C for 2 hours. After cooling the mixture to room temperature, 50 ml [OF 2N] hydrochloric acid were added thereto, followed by stirring at [50 C] for 2 hours. The resultant mixture was neutralized with sodium bicarbonate and extracted with dichloromethane, and the extract was dried and concentrated. The residue thus obtained was purified by silica gel column chromatography (eluent: ethyl [ACETATE/HEXANE=L/L)] to obtain 7.8 g of [1-{(TETRAHYDRO-3-FURANYL) METHYL}-2-NIERO-] 3-methylguanidine (dinotefuran).
124391-75-9, 124391-75-9 (S)-(Tetrahydrofuran-3-yl)methanol 40784875, aTetrahydrofurans compound, is more and more widely used in various fields.
Reference£º
Patent; THE HARTZ MOUNTAIN CORPORATION; WO2004/23873; (2004); A2;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem