453-20-3,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.453-20-3,3-Hydroxytetrahydrofuran,as a common compound, the synthetic route is as follows.
General procedure: To the mixture of 60% NaH (7.68 g, 0.053 mol), anhydrous THF (400 mL), (S)-tetrahydrofuran-3-ol (8.45 g, 0.096 mol) was added drop-wise at room temperature. The mixture was stirred at room temperature for 1 h a solution of compound 4a (10.0 g, 0.032 mol) in anhydrous THF (200 mL) was added via a dropping funnel over 1 h (the dropping funnel was rinsed with 15 mL of THF) at room temperature and the reaction mixture was stirred at room temperature for 2 h, the reaction was monitored by TLC. Then the solution was concentrated under a reduced pressure and the residue was poured into water with stirring, yielding a precipitate, then the mixture was filtered and washed with ice-water and ethanol, dried to afford compound 5b as yellow solid (9.8 g, 81.0%).
453-20-3 3-Hydroxytetrahydrofuran 9960, aTetrahydrofurans compound, is more and more widely used in various fields.
Reference£º
Article; OuYang, Yiqiang; Zou, Wensheng; Peng, Liang; Yang, Zunhua; Tang, Qidong; Chen, Mengzi; Jia, Shuang; Zhang, Hong; Lan, Zhou; Zheng, Pengwu; Zhu, Wufu; European Journal of Medicinal Chemistry; vol. 154; (2018); p. 29 – 43;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem