With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1679-47-6,3-Methyldihydrofuran-2(3H)-one,as a common compound, the synthetic route is as follows.
Example 11 Hydrogenation of alpha-methyl-gamma-butyrolactone [Ru2(mu-Cl)3(triphos)2]Cl (3.0 mg), potassium tert-butoxide (5.5 mg), and 1. 5 ml of methanol were added into a 20-ml Schlenk tube under a nitrogen atmosphere, and the mixture was stirred for 20 minutes at room temperature. This solution and alpha-methyl-gamma-butyrolactone (0.12 g) were added into a 100-ml autoclave having a stirrer placed inside, under a nitrogen atmosphere. The autoclave was purged with hydrogen, and then hydrogen was further included in the autoclave up to 4.0 MPa. The contents of the autoclave were heated and stirred at 100C for 13 hours. After cooling, the reaction liquid was analyzed by gas chromatography, and it was found that 1,4-pentanediol was produced at a yield of 39.7%., 1679-47-6
The synthetic route of 1679-47-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Takasago International Corporation; EP2141142; (2010); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem