149809-43-8, ((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methyl 4-methylbenzenesulfonate is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,149809-43-8
To a solution of 4-bromo-2-methyl phenol (920 mg, 4.89 mmol) in DMSO (10 mL) was added aq sodium hydroxide (0.39 mL, 12.5 M, 4.89 mmol) and the mixture stirred at RT for 10 min and then treated with the tosylate (IX) (2.00 g, 4.45 mmol). The reaction mixture was stirred at 60C for 72 hr then cooled to RT and partitioned between water (25 mL) and EtOAc (20 mL). The organic phase was separated and retained and the aq layer was extracted with EtOAc (3 x 25 mL). The combined organic extracts were washed with brine (3 x 15 mL) and then dried and evaporated in vacuo. The crude product was purified by flash column chromatography (S1O2, 12 g, 0-30% EtOAc in DCM, gradient elution) to give the title compound, intermediate (XIII), as a colourless oil (1.84 g, 86%); Rl 2.78 min (Method a); m/z 464 (M+H)+ (ES+); 1 H NMR delta: 2.09 (3H, s), 2.17 (1 H, dd), 2.37-2.43 (1 H, m), 2.52-2.60 (1 H, m), 3.72-3.78 (2H, m), 3.82 (1 H, dd), 4.00-4.06 (1 H, m), 4.57 (2H, dd), 6.82 (1 H, d), 7.00 (1 H, td), 7.25-7.34 (4H, m), 7.76 (1 H, s), 8.34 (1 H, s).
The synthetic route of 149809-43-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; PULMOCIDE LIMITED; SUNOSE, Mihiro; COLLEY, Thomas Christopher; ITO, Kazuhiro; RAPEPORT, Garth; STRONG, Peter; (55 pag.)WO2016/87878; (2016); A1;,
Tetrahydrofuran – Wikipedia
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