With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.184950-35-4,(Tetrahydrofuran-3-yl)methanamine hydrochloride,as a common compound, the synthetic route is as follows.
5- (naphthalen-1-ylmethyl) isoxazole-3-carboxylic acid (123 mg, 0.49 mmol), Tetrahydrofuran-3-ylmethylamine hydrochloride (123 mg, 0.90 mmol), Triethylamine (0.23 mL, 1.66 mmol) And 1-hydroxybenzotriazole (9 mg, 0.06 mmol) Was added to chloroform (amylene addition product) (5 mL). To the mixture, 1-Ethyl-3- (3-dimethylaminopropyl) carbodiimide hydrochloride (159 mg, 0.83 mmol) was added at room temperature, After stirring overnight, And concentrated under reduced pressure. The residue was subjected to silica gel column chromatography, Indicated below N- (tetrahydrofuran-3-ylmethyl) -5- (naphthalen-1-ylmethyl) isoxazole-3-carboxamide (Hereinafter referred to as the present amide compound (160)) 95 mg was obtained., 184950-35-4
184950-35-4 (Tetrahydrofuran-3-yl)methanamine hydrochloride 17750392, aTetrahydrofurans compound, is more and more widely used in various fields.
Reference£º
Patent; SUMITOMO CHEMICAL COMPANY LIMITED; SUMITA, YUSUKE; (264 pag.)JP2015/51963; (2015); A;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem