204512-95-8, (S)-Tetrahydrofuran-3-amine hydrochloride is a Tetrahydrofurans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A mixture of the compound obtained above (2.8 mmol), (S)- aminotetrahydrofuran hydrochloride (346 mg, 2.8 mmol) and DIEA (1.0 mL, 2.1 mmol) in DCM (6 mL) was stirred at -70 C (C02/i-PrOH) under an atmosphere of nitrogen. After 30 minutes the cooling bath was removed and the mixture was stirred overnight at room temperature. TLC analysis of the crude reaction mixture ([EtOAc/hexanes (3:7)] Rf = 0.56) showed the reaction to be complete. To the brown solution was then added DCM (2 mL), trans-4-aminocyclohexanol (323 mg, 2.8 mmol) and DIEA (1.0 mL, 2.1 mmol), and the reaction flask was sealed and stirred at 45 C overnight. After cooling to room temperature the contents of the reaction flask was added to a saturated NH4CI solution (25 mL) and water (10 mL). The product was extracted [2 x DCM (10 mL)] from the aqueous solution, dried (Na2S04) and the solvent was removed under reduced pressure. The crude product was purified by flash chromatography over silica gel [EtO Ac/heptane (9: 1), EtOAc] to provide 0.49 g (54%) of the target compound as a light yellow solid. TLC (EtO Ac) Rf = 6.27. HPLC conditions C, RT = 13.63 min (CP: 95.9%, radiochemical purity (RCP): 98.1%), 204512-95-8
As the paragraph descriping shows that 204512-95-8 is playing an increasingly important role.
Reference£º
Patent; SIGNAL PHARMACEUTICALS, LLC; BEAUCHAMPS, Marie, Georges; HARRIS, Louise, Michelle; KOTHARE, Mohit, Atul; SAINDANE, Manohar, T.; WO2011/71491; (2011); A1;,
Tetrahydrofuran – Wikipedia
Tetrahydrofuran | (CH2)3CH2O – PubChem